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Site-specific integration in the genome of malaria parasite Plasmodium falciparum, mediated by mycobacteriophage Bxb1. Cover by Erin Boyle, using images from David Fidock and CDC/James Gathany. Article p615
In this issue, the Withers laboratory takes advantage of the negatively charged sialic acid to develop a high-throughput screening technology that can be used for evolving glycosyltransferases with new enzymatic activities.
A new generation of fluorescent reagents offers researchers unprecedented visual access to the inner workings of cells—and even live animals. Michael Eisenstein examines the latest tools for live-cell and in vivo optical imaging.
