Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
From mutagenesis to gene therapy for hemophilia, transposons—mobile genetic elements—have proven themselves innovative tools in the laboratory and the clinic. Caitlin Smith takes a look at some present offerings of transposon products and the promise of applications.
A method of time-resolved two-photon volume imaging with cellular resolution allows for the first time a comprehensive analysis of cortical microcircuits in vivo.
A new maximum likelihood–based algorithm allows cryo-EM structure determination of macromolecular complexes even when conformational heterogeneity is present.