A new maximum likelihood–based algorithm allows cryo-EM structure determination of macromolecular complexes even when conformational heterogeneity is present.
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Sigworth, F. From cryo-EM, multiple protein structures in one shot. Nat Methods 4, 20–21 (2007). https://doi.org/10.1038/nmeth0107-20
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DOI: https://doi.org/10.1038/nmeth0107-20