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Volume 9 Issue 11, November 2003

Directing immune responses to kill tumor cells - by induction of apoptosis, for example - is a major goal of cancer immunotherapy. In this issue, Padua et al. (page 1413) present a vaccine strategy for treating promyelocytic leukemia, and Rubio et al. (page 1377) demonstrate a new method for detecting vaccine-induced tumorcytolytic T cells. The cover image shows a healthy human myeloid cell (upper cell) and a myeloid cell undergoing apoptosis (lower cell). Magnification, x11,000. Courtesy of Gopal Murti/Photo Researchers Inc.

Volume 9 Issue 11

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  • Molecules that regulate contraction in skeletal muscle have now found a place in the axon. In response to injury, the ryanodine receptor mediates the release of internal calcium stores, which contributes to axonal damage.

    • Jean R Wrathall
    News & Views

  • One approach to developing antiobesity drugs is to shift the energy balance in the body in favor of burning fat. A transcriptional coactivator is now assigned this task.

    • Robert Walczak
    • Peter Tontonoz
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  • Glucose transport into the cell is a delicate process that is highly responsive to insulin. A newly identified protein that may tether to the glucose transporter helps keep glucose traffic running smoothly in human cells.

    • Alan R Saltiel
    News & Views

  • Artemin reverses pain and neurochemical changes after nerve injury in an animal model. The molecule could potentially treat neuropathic pain, in which even the slightest touch can hurt (pages 1383–1389).

    • Halina Machelska
    • Paul A Heppenstall
    • Christoph Stein
    News & Views

  • Effective cancer vaccines targeted against specific antigens have eluded researchers for decades. When combined with a drug, one such vaccine now shrinks tumors in a mouse model of promyelocytic leukemia (pages 1413–1417).

    • John Donnelly
    News & Views

  • M. tuberculosis persists in the body, sequestered inside macrophages and subverting the phagocytic machinery to create a membrane-bound home. Microarray profiling studies reveal how the bacterium settles into its new environment.

    • John D McKinney
    • James E Gomez
    News & Views
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