Volume 11 Issue 10, 1 October 2005

Brief Communication

Technical Report

Article

Letter

Editorial

News

Foreword

Commentary

Book Review

News & Views

  • News & Views |

    Antibiotic discovery has been stalled for well over a decade. The discovery of a new antibiotic with an unexpected mechanism of action could reinvigorate this lagging field ( pages 1082–1087 ).

    • John S Blanchard
  • News & Views |

    The hormone adiponectin is secreted from fat cells and increases sensitivity to insulin in muscle and liver; adiponectin increases resistance to metabolic disorders and, it now appears, may also protect heart tissue when blood flow is restricted ( pages 1096–1103 ).

    • Koh-ichi Yuhki
    • , Jun-ichi Kawabe
    •  & Fumitaka Ushikubi
  • News & Views |

    In susceptible individuals, fasting can trigger an attack of acute porphyria—a syndrome caused by the neurotoxic effects of precursors to porphyrins. The mechanistic basis for this trigger is now uncovered.

    • John D Phillips
    •  & James P Kushner
  • News & Views |

    A new approach to tumor therapy combines two problematic cancer-fighting tools: tumor-targeted T cells and gene therapy. The T cells deliver a gene therapy vector to tumor cells, ensuring their destruction ( pages 1073–1081 ).

    • Cliona M Rooney
  • News & Views |

    Results now emerge from a preclinical trial of a heat-shock protein inhibitor in a mouse model of neurodegenerative disease. The data indicate that targeting a misfolded protein for degradation may be a useful therapeutic strategy (pages 1088–1095).

    • Albert R La Spada
    •  & Patrick Weydt
  • News & Views |

    Liver regeneration can occur by proliferation of two different cell types, but generally only one at a time is fully turned on. A factor that may specifically activate one of these cell types now comes to light.

    • Nelson Fausto