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Targeting toxic proteins for turnover

Nature Medicine volume 11, pages 1052–1053 (2005)Cite this article

Results now emerge from a preclinical trial of a heat-shock protein inhibitor in a mouse model of neurodegenerative disease. The data indicate that targeting a misfolded protein for degradation may be a useful therapeutic strategy (pages 1088–1095).

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Figure 1: Action of a heat-shock protein 90 inhibitor in the polyglutamine-repeat disease SBMA.

Katie Ris

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Authors and Affiliations

  1. Departments of Laboratory Medicine, Medicine and Neurology, and The Center for Neurogenetics & Neurotherapeutics, University of Washington, Seattle, 98195, Washington, USA

    Albert R La Spada

  2. Department of Laboratory Medicine, University of Washington, Seattle, 98195, Washington, USA

    Patrick Weydt

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  1. Albert R La Spada
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  2. Patrick Weydt
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Spada, A., Weydt, P. Targeting toxic proteins for turnover. Nat Med 11, 1052–1053 (2005). https://doi.org/10.1038/nm1005-1052

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