The hormone adiponectin is secreted from fat cells and increases sensitivity to insulin in muscle and liver; adiponectin increases resistance to metabolic disorders and, it now appears, may also protect heart tissue when blood flow is restricted (pages 1096–1103).
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Yuhki, Ki., Kawabe, Ji. & Ushikubi, F. Fat, keeping the heart healthy?. Nat Med 11, 1048–1049 (2005). https://doi.org/10.1038/nm1005-1048
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DOI: https://doi.org/10.1038/nm1005-1048