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α-Synuclein seeds have been identified in various tissues in patients with synucleinopathies. We have developed real-time quaking-induced conversion combined with immunoprecipitation, a method that enables the detection of α-synuclein seeds from the serum of patients with synucleinopathies. This method can lay the foundation for the biological diagnosis of synucleinopathies.
We performed multi-ancestry genome-wide meta-analyses of preeclampsia/eclampsia and gestational hypertension, identifying 12 susceptibility loci associated with one or both conditions. These analyses enabled the derivation of genome-wide polygenic risk scores, which predicted the development of these hypertensive pregnancy complications in independent cohorts, independent of clinical risk factors.
A newly composed single-cell transcriptomic atlas of tumor-infiltrating T cells across 16 cancer types revealed previously undescribed T cell states and heterogeneity. A unique T cell stress response state, TSTR, was linked to immunotherapy resistance. Our high-resolution T cell reference maps, web portal, and annotation tool can assist efforts to develop T cell therapies.
For women who choose nonhormonal therapy for hot flashes, fezolinetant appears to be one of several modestly efficacious and safe options — but women want more.
The health sector must play its part in decarbonization efforts; this Perspective outlines the principles of fair pathways to net-zero healthcare that are attentive to health and socioeconomic inequalities.
We characterized cancer cells, immune responses and the microbiota composition in a cohort of primary colon cancers. Multi-omic analyses defined parameters associated with favorable prognosis, including a score that captured the intratumoral immune response and a specific microbiome signature. This data repository (atlas and compass of immune–cancer–microbiome interactions (AC-ICAM)) is publicly available.
An antisense oligonucleotide therapy substantially reduced tau expression in a phase 1b trial; whether this translates to clinical improvement remains to be seen, but it could have far-reaching implications for neurodegenerative diseases more broadly.
Machine learning models that integrate cardiac troponin concentrations and clinical features to compute the probability of myocardial infarction outperform current care pathways that use fixed troponin thresholds or risk scores. Adoption of these models could reduce inequalities, prevent unnecessary admissions, and accelerate the diagnosis and treatment of patients with myocardial infarction.
Adding an oncolytic virus to classic immune checkpoint inhibition elicits treatment responses and survival benefit for select immunologically ‘cold’ recurrent glioblastomas, although creative treatment strategies are still needed for patients with highly anti-inflammatory tumors.
This Perspective outlines practical considerations for designing and testing visual displays to communicate health information, using illustrative case examples.
Diagnosis of kidney allograft rejection remains complex and somewhat subjective; but an automated version of the gold-standard Banff classification could streamline assessment and improve diagnostic accuracy.
An individual-level simulation model has been developed to evaluate the comparative effectiveness of maternal health policy interventions in 200 countries and territories. In addition to assessing global progress, this approach can guide priority setting and provide context-specific guidance for local policymakers.
Single-cell analyses in humans and mice have revealed the identity of the erythropoietin producing cells of the kidney — opening up new avenues of research for anemia and related disorders.
The CanScreen5 project provides a tool for monitoring the performance and improving the quality of global cancer screening programs — and highlights the importance of robust quality assurance in this setting.
By using several large population-based and clinical neuroimaging cohorts, we identified a shared neural basis for several mental disorders, namely the neuropsychopathological factor. This genetically determined factor might represent a delayed development of prefrontal brain neural circuits, leading to poor executive function.
A new study highlights the importance of dietary intake and a health-promoting food environment for diabetes prevention, but translating this into meaningful outcomes requires urgent government action.
The Outcome4Medicine consensus group outline recommendations for postoperative outcome assessment, with the ultimate goal of improving care quality and patient health.
Data from circulating tumor DNA (ctDNA) testing were generated for over 1,900 samples across at least 3 time points in a phase 3 clinical trial and used to build a machine learning model to predict patient survival. The model accurately identified patients with a high risk of disease recurrence and could provide a basis for assigning therapies in phase 1/2 clinical trials.
Salt substitutes can lower blood pressure and the incidence of cardiovascular disease, according to a new study — that also provides reassurance on safety.
