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The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A new study in mice identifies a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes.
Endogenous expression of tailored nanoparticles in cells followed by application of low-frequency radio waves or a magnetic field can be used to noninvasively modulate gene expression. This approach successfully induces insulin transgene expression in diabetic mice.
Notch signaling regulates developmental processes. A new study in mice shows that Notch signaling regulates the maintenance and survival of memory CD4+ T lymphocytes through a mechanism involving glucose uptake, and it suggests that Notch signaling can be modulated to treat autoimmune conditions.
