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Notch signaling maintains T cell memories

Nature Medicine volume 21, pages 16–18 (2015)Cite this article

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Notch signaling regulates developmental processes. A new study in mice shows that Notch signaling regulates the maintenance and survival of memory CD4+ T lymphocytes through a mechanism involving glucose uptake, and it suggests that Notch signaling can be modulated to treat autoimmune conditions.

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Figure 1: Notch signaling is required for maintenance of memory CD4+ T cells.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. La Jolla Institute for Allergy and Immunology and the Division of Hematology and Oncology, Aaron M. Miller and Stephen P. Schoenberger are at the Laboratory of Cellular Immunology, Moores Cancer Center, The University of California, San Diego, San Diego, California, USA.,

    Aaron M Miller & Stephen P Schoenberger

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  1. Aaron M Miller
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  2. Stephen P Schoenberger
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Correspondence to Stephen P Schoenberger.

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The authors declare no competing financial interests.

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Miller, A., Schoenberger, S. Notch signaling maintains T cell memories. Nat Med 21, 16–18 (2015). https://doi.org/10.1038/nm.3784

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