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Aging platelets stimulate TPO production

Nature Medicine volume 21, pages 11–12 (2015)Cite this article

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The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A new study in mice identifies a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes.

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Figure 1: Regulation of TPO production.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Benjamin T. Kile is at the Australian Cancer Research Foundation Chemical Biology Division, the Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.,

    Benjamin T Kile

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  1. Benjamin T Kile
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Correspondence to Benjamin T Kile.

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Kile, B. Aging platelets stimulate TPO production. Nat Med 21, 11–12 (2015). https://doi.org/10.1038/nm.3780

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