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Technological miniaturization combined with the power of molecular genetics makes the mouse a model animal for understanding human cardiovascular and pulmonary diseases.
Understanding the genetic defects underlying cystic fibrosis is only half the battle. Identifying the specific bacterium infecting CF patients is just as important (pages 661–666).
The gains made in life expectancy and against infant mortality in low-income nations are being accompanied by increases in mental-health-related problems.
The promising description of a potential basis for gene therapy in treating HIV infection does not mean that traditional approaches should be abandoned (pages 667–673).
The recent descriptions of T-cell dynamics in HIV disease have refocused efforts to understand the normal homeostatic processes that maintain T-cell populations (pages 674–680).
Mutations in tumour suppressors often lead to tumorigenesis. But other genetic mechanisms affecting suppressor gene expression can be just as effective (pages 686–692).
The role of the CD44 cell surface molecule in tumorigenesis has been the focus of intense debate. Now enough pieces are known to begin putting the puzzle together.
The finding that the drug clotrimazole has potent inhibitory effects on cell proliferation offers new challenges for therapy and biological investigation (pages 534–540).
The induction of ulcerative colitis in mice with targeted disruptions of a G protein-encoding gene establishes yet another genetic link between G proteins and disease.
The specific targeting of signal transduction components implicated in vascular disease may be accomplished more efficiently with genes than with drugs (pages 541–545).
Pollutant research is moving indoors as scientists uncover new links between indoor exposure and disease. However, measuring the levels of exposure is a difficult task.