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Mowat, Scott and Bain discuss the functions of barrier-tissue macrophages in homeostasis and disease, and how these are shaped by their local environment.
In this Review, Ferrando and López-Otín discuss the role of clonal evolution in leukemia and propose that better understanding of the evolutionary biography of human leukemias and related blood cell malignancies may contribute to improve their clinical management.
In this Review, Salter and Stevens discuss the role of microglia in CNS disorders such as autism, neurodegenerative disorders, Alzheimer’s disease, and chronic pain.
In this Review, David Fidock discusses malarial resistance to artemisinin-based combination therapies, among others, and presents strategies for designing new therapeutics and to overcome resistance.
In this Review, Cathomen and colleagues present the latest advances, including improvements in nuclease specificity and delivery, that will expedite the clinical translation of genome editing.
Two decades ago, α-synuclein was identified as a key player in Parkinson's disease pathogenesis. Wong and Krainc review the upstream factors and downstream cellular mechanisms associated with α-synuclein toxicity and discuss therapeutic efforts to target synucleinopathies.
Gattinoni and colleagues discuss the emerging roles of this subset of long-lived memory T lymphocytes, and highlight ways in which these cells might be exploited to achieve therapeutic aims.
Patterns of splicing are frequently altered in cancer, and genes that encode splicing regulatory factors are often mutated. Thus, recent strategies have emerged to target splicing alterations in cancer, which are reviewed here.
Toren Finkel reviews how metabolism and aging are connected, and highlights pathways that could be pharmacologically targeted to combat aging and age-related disease.
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting these cells to counteract disease.
Maite Huarte discusses our current understanding of the impact of long noncoding RNAs on tumor growth and progression, and how this knowledge might be translated into new therapeutic approaches.
Recent studies have provided insight into how the environment, and in particular the diet, influence the development of lymphocytes. Emerging studies indicate a role for this immune development in inflammatory disease.
Tissue-resident memory T cells are increasingly being linked to human tissue-specific immune and inflammatory disease. These roles are discussed in this review.