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Building on a pre-existing pooling pipeline for the efficient detection of SARS-CoV-2, the results of a large-scale implementation study show the feasibility and benefits of saliva sample pooling to enhance neonatal screening for congenital cytomegalovirus.
An observational study reports the joint effects of polygenic risk scores and radiation treatment exposure with a subsequent increased risk of multiple solid cancers in two large cohorts of survivors of childhood cancer.
In a large trial of patients with recurrent high-grade gliomas, IL-13Rα2-targeting CAR-T cells were feasible to manufacture and well tolerated when delivered via intratumoral and/or intraventricular routes.
Self-care interventions have the potential to improve health coverage for women while offering greater agency and autonomy, but only if certain barriers—such as stigma and cost—can be overcome.
Clonal hematopoiesis, which increases with age and is implicated in a variety of age-related diseases, is shown here to be associated with a greater risk of acute kidney injury and worse outcome following injury, as demonstrated using multiple patient cohorts, Mendelian randomization analysis and mechanistic studies in mouse disease models.
Automated insulin delivery systems have transformed the care of people living with type 1 diabetes and continue to move closer to the ultimate goal of a fully autonomous artificial pancreas.
Growing evidence shows that lower doses or shorter treatments of precision cancer therapies could reduce toxicity and save money — but more clinical trials are needed.
A multi-ancestry analysis in large cohorts of patients with type 2 diabetes (T2D) identified 12 disease genetic clusters with distinct cardiometabolic trait associations, including two lipodystrophy-related clusters that could provide insights on the increased T2D susceptibility in East Asian ancestries at a given body mass index level.
A modeling study of 35 cholera-affected countries in Africa showed that introducing cholera surveillance could improve the effectiveness and cost-effectiveness of preventive cholera vaccination campaigns.
Primary fetal organoids are currently derived from tissue samples obtained at termination of pregnancy. We developed an approach that enables prenatal derivation of epithelial organoids from fetal fluids. Single-cell mapping of the human amniotic fluid content unveiled the presence of viable fetal epithelial progenitors of multiple tissues that can form fetal lung, kidney and intestinal organoids.
In a randomized phase 2 trial comparing anti-PD-1 plus anti-VEGF plus an HDAC inhibitor versus anti-PD-1 plus an HDAC inhibitor in patients with MSS/pMMR colorectal cancer, the triplet combination led to significantly better 18-week progression-free survival.
The generation of primary organoids, from fetal fluid-derived epithelial stem or progenitor cells, offers the possibility of modeling different developing tissues during gestation, even beyond the limits of pregnancy termination.
A cross-ancestry meta-analysis identified 126 genetic loci associated with chronic pain intensity, revealing correlations with substance use and psychiatric traits.
Efforts to identify microbial signatures of response to immune checkpoint blockade suggest that strain-level associations may be cancer type agnostic but cancer therapy specific.