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HIV-1 is initially controlled by host effector CTLs but finally evades immune surveillance through CTL escape virus mutants, resulting in progression to AIDS (pages 205–211).
Treatment of hypercholesterolemia by transplantation of xenogeneic hepatocytes presents new challenges and opportunities to immunologists (pages 48–53).
Evidence is accumulating that presenilin gene mutations may contribute to the pathogenesis of Alzheimer's disease by increasing amyloid β-protein production (pages 67–72).