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Xenotransplanting hepatocytes: The triumph of a cup half full

Treatment of hypercholesterolemia by transplantation of xenogeneic hepatocytes presents new challenges and opportunities to immunologists (pages 48–53).

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References

  1. Gunsalus, J.R., Brady, D.A., Coulter, S.M., Gray, B.M. & Edge, A. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nature Med. 3, 48–53 (1997).

    Article  CAS  Google Scholar 

  2. Brown, M.S. & Goldstein, J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34–47 (1986).

    Article  CAS  Google Scholar 

  3. Reid, L.M., cell/lineage biology and lineage-dependent extra Cellular matrix chemistry: keys to tissue engineering of quiescent tissues such as liver. Textbook of Tissue Engineering (eds. Lanza, R.P. & Langer,R.) (Landes, Austin, TX, in the press).

  4. Harbrecht, B.G. & Billiar, T.R. The role of nitric oxide in Kupffer Cell-hepatocyte interactions. Shock 3, 79–8 (1995).

    Article  CAS  Google Scholar 

  5. Lenschow, D.J. et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science 257, 789–792 (1992).

    Article  CAS  Google Scholar 

  6. Zhao, Y. et al. Skin graft tolerance across a discordant xenogeneic barrier. Nature Med. 2, 1211–1216 (1996).

    Article  CAS  Google Scholar 

  7. Sachs, D.H. & Sablinski, T. Tolerance across discordant xenogeneic barriers. Xenotransplantation 2, 234–239 (1995).

    Article  Google Scholar 

  8. Sriwatanawongsa, V., Davies, H.FF.S. & Calne, R.Y. The essential roles of parenchymal tissues and passenger leukocytes in the tolerance induced by liver grafting in rats. Nature Med. 1, 428–432 (1995).

    Article  CAS  Google Scholar 

  9. Starzl, T.E. et al. Cell migration, chimerism, and graft acceptance. Lancet 339, 1579–1582 (1992).

    Article  CAS  Google Scholar 

  10. Ando, K., Guidotti, L.G., Cerny, A., Ishikawa, T. & Chisari, F.V. CTL access to tissue antigen is re stricted in vivo. J. Immunol. 153, 482–488 (1994).

    CAS  PubMed  Google Scholar 

  11. Parker, W. et al. Transplantation of discordant xenografts: A challenge revisited. Immunol. Today 17, 373–378 (1996).

    Article  CAS  Google Scholar 

  12. Sharma, A., Okabe, J.F., Birch, P., Platt, J.L. & Logan, J.S. Reduction in the level of gal (α1,3)gal in transgenic mice and pigs by the expression of an α(1,2)fucosyltransferase. Proc. Natl. Acad. Sci. USA 93, 7190–7195 (1996).

    Article  CAS  Google Scholar 

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Platt, J. Xenotransplanting hepatocytes: The triumph of a cup half full. Nat Med 3, 26–27 (1997). https://doi.org/10.1038/nm0197-26

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