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Volume 5 Issue 3, March 2004

T cells become nonresponsive, or anergic, in certain Ca2+-dependent conditions. Rao and colleagues (p 255; News and Views by Ben-Neriah, p 238) find that anergy proceeds in a stepwise way that targets the degradation of key signaling components. Ultimately, the outer ring of LFA-1 adhesion proteins (red) in the immune synapse starts to dissolve away from the inner T cell receptors (green). Original photo by Rajat Varma; artwork is Lewis Long.

Volume 5 Issue 3

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Commentary

  • Eliciting broadly neutralizing antibodies to human immunodeficiency virus could bring closer the goal of a successful AIDS vaccine. Here the International AIDS Vaccine Initiative Neutralizing Antibody Consortium discusses current approaches to overcome the problems faced.

    • Dennis R Burton
    • Ronald C Desrosiers
    • Richard T Wyatt
    Commentary
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News & Views

  • Natural killer cells are kept in check by their inhibitory receptors. Data now indicate that these receptors can bind ligands that are next to them on the same cell surface, with unexpected functional consequences.

    • Paul J Leibson
    • Larry R Pease
    News & Views

  • Anergy induction initiates a transcription program involving the upregulation of several ubiquitin ligases (E3s). New data show how these E3s contribute to the establishment of anergy.

    • Matti Davis
    • Yinon Ben-Neriah
    News & Views

  • When acetyl or methyl groups are added to histones, chromatin structure and gene expression are altered. The methyltransferase G9a can target the specific silencing of IFNB gene expression and blocking of V(D)J recombination.

    • Karen W Makar
    • Christopher B Wilson
    News & Views

  • Viral TH1 responses can positively regulate TH2 responses in a mouse model of allergen-induced lung inflammation. This helps explain why respiratory viral infections can exacerbate allergic TH2-type diseases.

    • Richard J Riese
    • Patricia W Finn
    • Steven D Shapiro
    News & Views
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