Anergy induction initiates a transcription program involving the upregulation of several ubiquitin ligases (E3s). New data show how these E3s contribute to the establishment of anergy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kang, S.M. et al. Science 257, 1134–1138 (1992).
Schwartz, R.H. Annu. Rev. Immunol. 21, 305–334 (2003).
Macian, F. et al. Cell 109, 719–731 (2002).
Heissmeyer, V. et al. Nat. Immunol. 5, 255–265 (2004).
Schnell, J.D. & Hicke, L. J. Biol. Chem. 278, 35857–35860 (2003).
Krawczyk, C. & Penninger, J.M. Trends Cell Biol. 11, 212–220 (2001).
Lee, K.H. et al. Science 302, 1218–1222 (2003).
Iezzi, G., Karjalainen, K. & Lanzavecchia, A. Immunity 8, 89–95 (1998).
Fang, D. et al. Nat. Immunol. 3, 281–287 (2002).
Anandasabapathy, N. et al. Immunity 18, 535–547 (2003).
Angers, A., Ramjaun, A.R. & McPherson, P.S. J. Biol. Chem. advance online publication, 18 December 2003 (doi:10.1074/jbc.M309934200).
Sasahara, Y. et al. Mol. Cell 10, 1269–1281 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davis, M., Ben-Neriah, Y. Behind the scenes of anergy: a tale of three E3s. Nat Immunol 5, 238–240 (2004). https://doi.org/10.1038/ni0304-238
Issue Date:
DOI: https://doi.org/10.1038/ni0304-238
This article is cited by
-
Multifaceted role of the ubiquitin ligase Itch in immune regulation
Immunology & Cell Biology (2015)