Volume 15 Issue 3, March 2014

Volume 15 Issue 3

Loss of the transcription factor Ikaros is associated with a poor prognosis for certain leukemias. Georgopoulos and colleagues (p 294) show that loss of Ikaros arrests B lymphoid progenitors at an adherent and proliferative pre-B cell stage. The original image shows Ikaros-deficient pre-B cells (blue) with enhanced adhesion to bone marrow stroma (green) and more activity of the kinase FAK (red).Artwork by Lewis Long.


Meeting Report

  • Meeting Report |

    Progress in understanding the multifaceted biology of B cells and their multiple contributions to autoimmunity is providing productive understanding of disease pathogenesis and is leading to novel strategies for therapeutic intervention.

    • Moncef Zouali

News and Views

  • News & Views |

    Hyperactivity of a branch of the unfolded protein response in CD8α+ dendritic cells degrades endoplasmic reticulum–associated mRNAs, which leads to a defect in the cross-presentation of dead cell–derived antigens.

    • Manikandan Subramanian
    •  & Ira Tabas
  • News & Views |

    Phosphorylation of the adhesion molecule VE-cadherin at tyrosine residues modulates the opening of endothelial junctions during inflammatory reactions. The replacement of two distinct residues in VE-cadherin shows that Tyr685 regulates vascular permeability and Tyr731 regulates leukocyte diapedesis in vivo.

    • Adama Sidibé
    •  & Beat A Imhof
  • News & Views |

    Naive T cells differentiate into memory subsets upon exposure to their cognate foreign antigen. However, before such encounters, some naive T cells are 'imprinted' through their interactions with self targets.

    • Christopher E Martin
    •  & Charles D Surh
  • News & Views |

    The viability of long-lived plasma cells is enhanced by the expression of inducible nitric oxide synthase, which relieves endoplasmic reticulum stress by triggering a response dependent on cGMP and protein kinase G.

    • Modesta N Njau
    •  & Joshy Jacob

Research Highlights