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Inducible nitric oxide synthase is crucial for plasma cell survival

Nature Immunology volume 15, pages 219–221 (2014)Cite this article

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The viability of long-lived plasma cells is enhanced by the expression of inducible nitric oxide synthase, which relieves endoplasmic reticulum stress by triggering a response dependent on cGMP and protein kinase G.

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Figure 1: A working model for iNOS-mediated enhancement of plasma cell survival.

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Authors and Affiliations

  1. Department of Microbiology & Immunology and Yerkes National Primate Center, Modesta N. Njau and Joshy Jacob are with the Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.,

    Modesta N Njau & Joshy Jacob

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  1. Modesta N Njau
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  2. Joshy Jacob
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Correspondence to Joshy Jacob.

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Njau, M., Jacob, J. Inducible nitric oxide synthase is crucial for plasma cell survival. Nat Immunol 15, 219–221 (2014). https://doi.org/10.1038/ni.2831

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