Nature Immunology has just turned five. To celebrate our 5 years of serving the immunology community, we have assembled a collection of papers that illustrates the breadth of subject matter our pages cover. Each article has stimulated productive discussion in the community and has helped drive the immunology field forward. In addition, these articles portray the types of papers Nature Immunology strives to publish: high-quality research that provides fundamental insight into the workings of the immune system.
For those immunologists less familiar with the scope of Nature Immunology, we have made this collection of articles available free online for 1 month. As you will see, the areas covered include (but are not limited to) innate immunity and inflammation, development, immune receptors, signaling, antigen presentation, gene regulation and recombination, cellular and systemic immunity, immune tolerance and microbial immunopathology. After all, our motto is "Immunology. All of it."
Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages Diefenbach, A., Jamieson, A.M., Liu, S.D., Shastri, N. and Raulet, D.H. Nature Immunology1, 119-126 (2000)|doi:10.1038/ni77793 Abstract|Full text|PDF
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria Ayabe, T., Satchell, D.P., Wilson, C.L., Parks, W.C., Selsted, M.E. & Ouellette, A.J. Nature Immunology1, 113-118 (2000)|doi:10.1038/ni77783 Abstract|Full text|PDF
Toll-like receptors control activation of adaptive immune responses Schnare, M., Barton, G.M., Holt, A.C., Takeda, K., Akira, S. and Medzhitov, R. Nature Immunology2, 947-950 (2001)|doi:10.1038/ni712 Abstract|Full text|PDF
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Nature Immunology2, 1032-1039 (2001)|doi:10.1038/ni723 Abstract|Full text|PDF
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide Jordan, M.S., Boesteanu, A., Reed, A.J., Petrone, A.L., Holenbeck, A.E., Lerman, M.A., Naji, A. & Caton, A.J. Nature Immunology2, 301-306 (2001)|doi:10.1038/86302 Abstract|Full text|PDF
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells Kaech, S.M. & Ahmed, R. Nature Immunology2, 415-422 (2001)|doi:10.1038/87720 Abstract|Full text|PDF
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology Asselin-Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter-Dambuyant, C., Vicari, A., O'Garra, A., Biron, C., Briere, F. & Trinchieri, G. Nature Immunology2, 1144-1150 (2001)|doi:10.1038/ni736 Abstract|Full text|PDF
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors Migueles, S.A., Laborico, A.C., Shupert, W.L., Sabbaghian, M.S., Rabin, R., Hallahan, C.W., Van Baarle, D., Kostense, S., Miedema, F., McLaughlin, M., Ehler, L., Metcalf, J., Liu, S. and Connors, M. Nature Immunology3, 1061-1068 (2002)|doi:10.1038/ni845 Abstract|Full text|PDF
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains Gadola, S.D., Zaccai, N.R., Harlos, K., Shepherd, D., Castro-Palomino, J.C., Ritter, G., Schmidt, R.R., Jones, E.Y. & Cerundolo, V. Nature Immunology3, 721-726 (2002)|doi:10.1038/ni821 Abstract|Full text|PDF
Programmed contraction of CD8+ T cells after infection Badovinac, V.P., Porter, B.B. & Harty, J.T. Nature Immunology3, 619-626 (2002)|doi:10.1038/ni804 Abstract|Full text|PDF
CTLA-4—Ig regulates tryptophan catabolism in vivo Grohmann, U., Orabona, C., Fallarino, F., Vacca, C., Calcinaro, F., Falorni, A., Candeloro, P., Belladonna, M.L., Bianchi, R., Fioretti, M.C. & Puccetti, P. Nature Immunology3, 1097-1101 (2002)|doi:10.1038/ni846 Abstract|Full text|PDF
The Drosophila immune system detects bacteria through specific peptidoglycan recognition Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.-H., Caroff, M., Lee, W.-J., Mengin-Lecreulx, D. & Lemaitre, B. Nature Immunology4, 478-484 (2003)|doi:10.1038/ni922 Abstract|Full text|PDF
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 Iwakoshi, N.N., Lee, A.-H., Vallabhajosyula, P., Otipoby, K.L., Rajewsky, K. & Glimcher, L.H. Nature Immunology4, 321-329 (2003)|doi:10.1038/ni907 Abstract|Full text|PDF
IKKε and TBK1 are essential components of the IRF3 signaling pathway in vivo Fitzgerald, K.A., McWhirter, S.M., Faia, K.L., Rowe, D.C., Latz, E., Golenbock, D.T., Coyle, A.J., Liao, S.-M. & Maniatis, T. Nature Immunology3, 491-496 (2003)|doi:10.1038/ni921 Abstract|Full text|PDF
The RNA helicase RIG-I has an essential function in double-stranded RNA�induced innate antiviral responses Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S. & Fujita, T. Nature Immunology5, 730-737 (2004)|doi:10.1038/ni1087 Abstract|Full text|PDF
Circulating hematopoietic progenitors with T lineage potential Schwarz, B.A. & Bhandoola, A. Nature Immunology5, 953-960 (2004)|doi:10.1038/ni1101 Abstract|Full text|PDF
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection Sun, J.C., Williams, M.A. & Bevan, M.J. Nature Immunology5, 927-933 (2004)|doi:10.1038/ni1105 Abstract|Full text|PDF
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse Li, Q.-J., Dinner, A.R., Qi, S., Irvine, D.J., Huppa, J.B., Davis, M.M. & Chakraborty, A.K. Nature Immunology5, 791-799 (2004)|doi:10.1038/ni1095 Abstract|Full text|PDF
