Guo and colleagues present a method known as CM-Drug for the identification of combination drugs that can boost the efficacy of immune checkpoint blockade therapy. They validate this method using melanoma and lung cancer models in mice and explore one hit from their screen in further depth, the thyrotropin-releasing hormone (TRH) analogue taltirelin.

See Guo et al.

March is Women’s History Month. This month’s issue celebrates the contributions of female neuroimmunologists.

For more information, see the Women in Immunology Collection

Yin et al. use Olink proteomics and single‐cell RNA sequencing (scRNA-seq) analyses to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months after infection with SARS-CoV-2.

See Kailin Yin et al.

Induced pluripotent stem (iPS) cell-derived macrophages (iMACs) are being used to engineer CAR macrophages for immunotherapy. Zhang and colleagues design second-generation macrophage-specific CARs by integrating CD3ζ and TIR domains, resulting in M1-polarized CAR-iMACs with increased antitumor functions.

See Zhang et al.