Volume 50 Issue 9, September 2018

Volume 50 Issue 9

The braided stream

View from above onto the wild river valley alluvial land of Yarlung Tsangpo Jiang (Brahmaputra) in Tibet, China. A braided river inspires models of population and species histories that may be richer and more complex than the bifurcations of a tree.

“The genome revolution has taught us that great mixtures of highly divergent populations have occurred repeatedly. Instead of a tree, a better metaphor may be a trellis, branching and remixing far back into the past.”

David Reich, Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past (Pantheon, New York, 2018)

“Evidence for genome-wide contradictions between gene trees and species trees is rapidly accumulating in a wide range of species, raising the question of whether this should lead to a reevaluation of the utility of the tree as model for speciation.”

Polina Yu Novikova et al. Nat. Genet. 48, 1077–1082, 2016

Image: Stefan Auth (Alamy). Cover Design: Erin Dewalt.

Editorial

  • Editorial |

    Precision genomic medicine is now technically feasible. Just as global positioning systems revolutionized the logistics of travel, so genome-wide polygenic risk scores (GPSs) now have the potential to inform our trajectories of health and to serve in the prevention and mitigation of many common and complex diseases. We welcome research into the implementation of—and equity of access to—genetic predictors and their integration into clinical and evidence-based medical practice.

Correspondence

News & Views

  • News & Views |

    Two new studies show that a plant-specific complex composed of EBS, or its homolog SHL, and EMF1 acts as a chromatin reader within the Polycomb pathway and effects gene repression. Two domains of EBS and SHL bind distinct chromatin modifications that are associated with active and repressed chromatin.

    • Kristin Krause
    •  & Franziska Turck
  • News & Views |

    A new study uncovers novel copy number signatures in ovarian cancer genomes. This work sheds light on mutational processes driving ovarian cancer, reveals the distribution of copy number features across the patient population and identifies new genomic properties related to treatment response.

    • Sohrab P. Shah
  • News & Views |

    Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility have been shown to yield both reliable and clinically meaningful results. However, certain impediments and outdated ways of thinking about health maintenance must be overcome before GPSs are adopted in routine care streams.

    • Andrew J. Schork
    • , M. Anthony Schork
    •  & Nicholas J. Schork

Perspectives

  • Perspective |

    This proposal calls for the initiation of national population-screening programs to identify carriers of cancer gene mutations for long-term, large-scale analysis of longitudinal clinical data to aid in prevention and early detection of disease.

    • Clare Turnbull
    • , Amit Sud
    •  & Richard S. Houlston

Letters

  • Letter |

    Genome-wide polygenic risk scores derived from GWAS data for five common diseases can identify subgroups of the population with risk approaching or exceeding that of a monogenic mutation.

    • Amit V. Khera
    • , Mark Chaffin
    • , Krishna G. Aragam
    • , Mary E. Haas
    • , Carolina Roselli
    • , Seung Hoan Choi
    • , Pradeep Natarajan
    • , Eric S. Lander
    • , Steven A. Lubitz
    • , Patrick T. Ellinor
    •  & Sekar Kathiresan
  • Letter |

    This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

    • Carolina Roselli
    • , Mark D. Chaffin
    • , Lu-Chen Weng
    • , Stefanie Aeschbacher
    • , Gustav Ahlberg
    • , Christine M. Albert
    • , Peter Almgren
    • , Alvaro Alonso
    • , Christopher D. Anderson
    • , Krishna G. Aragam
    • , Dan E. Arking
    • , John Barnard
    • , Traci M. Bartz
    • , Emelia J. Benjamin
    • , Nathan A. Bihlmeyer
    • , Joshua C. Bis
    • , Heather L. Bloom
    • , Eric Boerwinkle
    • , Erwin B. Bottinger
    • , Jennifer A. Brody
    • , Hugh Calkins
    • , Archie Campbell
    • , Thomas P. Cappola
    • , John Carlquist
    • , Daniel I. Chasman
    • , Lin Y. Chen
    • , Yii-Der Ida Chen
    • , Eue-Keun Choi
    • , Seung Hoan Choi
    • , Ingrid E. Christophersen
    • , Mina K. Chung
    • , John W. Cole
    • , David Conen
    • , James Cook
    • , Harry J. Crijns
    • , Michael J. Cutler
    • , Scott M. Damrauer
    • , Brian R. Daniels
    • , Dawood Darbar
    • , Graciela Delgado
    • , Joshua C. Denny
    • , Martin Dichgans
    • , Marcus Dörr
    • , Elton A. Dudink
    • , Samuel C. Dudley
    • , Nada Esa
    • , Tonu Esko
    • , Markku Eskola
    • , Diane Fatkin
    • , Stephan B. Felix
    • , Ian Ford
    • , Oscar H. Franco
    • , Bastiaan Geelhoed
    • , Raji P. Grewal
    • , Vilmundur Gudnason
    • , Xiuqing Guo
    • , Namrata Gupta
    • , Stefan Gustafsson
    • , Rebecca Gutmann
    • , Anders Hamsten
    • , Tamara B. Harris
    • , Caroline Hayward
    • , Susan R. Heckbert
    • , Jussi Hernesniemi
    • , Lynne J. Hocking
    • , Albert Hofman
    • , Andrea R. V. R. Horimoto
    • , Jie Huang
    • , Paul L. Huang
    • , Jennifer Huffman
    • , Erik Ingelsson
    • , Esra Gucuk Ipek
    • , Kaoru Ito
    • , Jordi Jimenez-Conde
    • , Renee Johnson
    • , J. Wouter Jukema
    • , Stefan Kääb
    • , Mika Kähönen
    • , Yoichiro Kamatani
    • , John P. Kane
    • , Adnan Kastrati
    • , Sekar Kathiresan
    • , Petra Katschnig-Winter
    • , Maryam Kavousi
    • , Thorsten Kessler
    • , Bas L. Kietselaer
    • , Paulus Kirchhof
    • , Marcus E. Kleber
    • , Stacey Knight
    • , Jose E. Krieger
    • , Michiaki Kubo
    • , Lenore J. Launer
    • , Jari Laurikka
    • , Terho Lehtimäki
    • , Kirsten Leineweber
    • , Rozenn N. Lemaitre
    • , Man Li
    • , Hong Euy Lim
    • , Henry J. Lin
    • , Honghuang Lin
    • , Lars Lind
    • , Cecilia M. Lindgren
    • , Marja-Liisa Lokki
    • , Barry London
    • , Ruth J. F. Loos
    • , Siew-Kee Low
    • , Yingchang Lu
    • , Leo-Pekka Lyytikäinen
    • , Peter W. Macfarlane
    • , Patrik K. Magnusson
    • , Anubha Mahajan
    • , Rainer Malik
    • , Alfredo J. Mansur
    • , Gregory M. Marcus
    • , Lauren Margolin
    • , Kenneth B. Margulies
    • , Winfried März
    • , David D. McManus
    • , Olle Melander
    • , Sanghamitra Mohanty
    • , Jay A. Montgomery
    • , Michael P. Morley
    • , Andrew P. Morris
    • , Martina Müller-Nurasyid
    • , Andrea Natale
    • , Saman Nazarian
    • , Benjamin Neumann
    • , Christopher Newton-Cheh
    • , Maartje N. Niemeijer
    • , Kjell Nikus
    • , Peter Nilsson
    • , Raymond Noordam
    • , Heidi Oellers
    • , Morten S. Olesen
    • , Marju Orho-Melander
    • , Sandosh Padmanabhan
    • , Hui-Nam Pak
    • , Guillaume Paré
    • , Nancy L. Pedersen
    • , Joanna Pera
    • , Alexandre Pereira
    • , David Porteous
    • , Bruce M. Psaty
    • , Sara L. Pulit
    • , Clive R. Pullinger
    • , Daniel J. Rader
    • , Lena Refsgaard
    • , Marta Ribasés
    • , Paul M. Ridker
    • , Michiel Rienstra
    • , Lorenz Risch
    • , Dan M. Roden
    • , Jonathan Rosand
    • , Michael A. Rosenberg
    • , Natalia Rost
    • , Jerome I. Rotter
    • , Samir Saba
    • , Roopinder K. Sandhu
    • , Renate B. Schnabel
    • , Katharina Schramm
    • , Heribert Schunkert
    • , Claudia Schurman
    • , Stuart A. Scott
    • , Ilkka Seppälä
    • , Christian Shaffer
    • , Svati Shah
    • , Alaa A. Shalaby
    • , Jaemin Shim
    • , M. Benjamin Shoemaker
    • , Joylene E. Siland
    • , Juha Sinisalo
    • , Moritz F. Sinner
    • , Agnieszka Slowik
    • , Albert V. Smith
    • , Blair H. Smith
    • , J. Gustav Smith
    • , Jonathan D. Smith
    • , Nicholas L. Smith
    • , Elsayed Z. Soliman
    • , Nona Sotoodehnia
    • , Bruno H. Stricker
    • , Albert Sun
    • , Han Sun
    • , Jesper H. Svendsen
    • , Toshihiro Tanaka
    • , Kahraman Tanriverdi
    • , Kent D. Taylor
    • , Maris Teder-Laving
    • , Alexander Teumer
    • , Sébastien Thériault
    • , Stella Trompet
    • , Nathan R. Tucker
    • , Arnljot Tveit
    • , Andre G. Uitterlinden
    • , Pim Van Der Harst
    • , Isabelle C. Van Gelder
    • , David R. Van Wagoner
    • , Niek Verweij
    • , Efthymia Vlachopoulou
    • , Uwe Völker
    • , Biqi Wang
    • , Peter E. Weeke
    • , Bob Weijs
    • , Raul Weiss
    • , Stefan Weiss
    • , Quinn S. Wells
    • , Kerri L. Wiggins
    • , Jorge A. Wong
    • , Daniel Woo
    • , Bradford B. Worrall
    • , Pil-Sung Yang
    • , Jie Yao
    • , Zachary T. Yoneda
    • , Tanja Zeller
    • , Lingyao Zeng
    • , Steven A. Lubitz
    • , Kathryn L. Lunetta
    •  & Patrick T. Ellinor

    Collection:

  • Letter |

    Large-scale association analyses identify 142 independent risk variants for atrial fibrillation. Pathway and functional enrichment analyses suggest that many of the putative risk genes act via cardiac structural remodeling.

    • Jonas B. Nielsen
    • , Rosa B. Thorolfsdottir
    • , Lars G. Fritsche
    • , Wei Zhou
    • , Morten W. Skov
    • , Sarah E. Graham
    • , Todd J. Herron
    • , Shane McCarthy
    • , Ellen M. Schmidt
    • , Gardar Sveinbjornsson
    • , Ida Surakka
    • , Michael R. Mathis
    • , Masatoshi Yamazaki
    • , Ryan D. Crawford
    • , Maiken E. Gabrielsen
    • , Anne Heidi Skogholt
    • , Oddgeir L. Holmen
    • , Maoxuan Lin
    • , Brooke N. Wolford
    • , Rounak Dey
    • , Håvard Dalen
    • , Patrick Sulem
    • , Jonathan H. Chung
    • , Joshua D. Backman
    • , David O. Arnar
    • , Unnur Thorsteinsdottir
    • , Aris Baras
    • , Colm O’Dushlaine
    • , Anders G. Holst
    • , Xiaoquan Wen
    • , Whitney Hornsby
    • , Frederick E. Dewey
    • , Michael Boehnke
    • , Sachin Kheterpal
    • , Bhramar Mukherjee
    • , Seunggeun Lee
    • , Hyun M. Kang
    • , Hilma Holm
    • , Jacob Kitzman
    • , Jordan A. Shavit
    • , José Jalife
    • , Chad M. Brummett
    • , Tanya M. Teslovich
    • , David J. Carey
    • , Daniel F. Gudbjartsson
    • , Kari Stefansson
    • , Gonçalo R. Abecasis
    • , Kristian Hveem
    •  & Cristen J. Willer

    Collection:

  • Letter |

    This study identifies a set of critical dependency genes in MYCN-amplified neuroblastoma that make up the oncogenic transcriptional regulatory circuitry underlying cell state and tumor survival.

    • Adam D. Durbin
    • , Mark W. Zimmerman
    • , Neekesh V. Dharia
    • , Brian J. Abraham
    • , Amanda Balboni Iniguez
    • , Nina Weichert-Leahey
    • , Shuning He
    • , John M. Krill-Burger
    • , David E. Root
    • , Francisca Vazquez
    • , Aviad Tsherniak
    • , William C. Hahn
    • , Todd R. Golub
    • , Richard A. Young
    • , A. Thomas Look
    •  & Kimberly Stegmaier
  • Letter |

    EBS, which prevents premature flowering in Arabidopsis, is shown to bind H3K27me3 and H3K4me3 via different domains. Disruption of either EBS–H3K27me3 or EBS–H3K4me3 interaction induces early floral transition.

    • Zhenlin Yang
    • , Shuiming Qian
    • , Ray N. Scheid
    • , Li Lu
    • , Xiangsong Chen
    • , Rui Liu
    • , Xuan Du
    • , Xinchen Lv
    • , Melissa D. Boersma
    • , Mark Scalf
    • , Lloyd M. Smith
    • , John M. Denu
    • , Jiamu Du
    •  & Xuehua Zhong

Articles

  • Article |

    Two BAH-domain-containing proteins (SHL and EBS) form a complex with EMF1, reading and effecting the H3K27me3 mark in Arabidopsis. The BAH-EMF1c complex thus shows PRC1-like functions in higher plants.

    • Zicong Li
    • , Xing Fu
    • , Yizhong Wang
    • , Renyi Liu
    •  & Yuehui He
  • Article |

    The authors identify copy number signatures from shallow whole-genome sequencing of high-grade serous ovarian cancer (HGSOC) cases. HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.

    • Geoff Macintyre
    • , Teodora E. Goranova
    • , Dilrini De Silva
    • , Darren Ennis
    • , Anna M. Piskorz
    • , Matthew Eldridge
    • , Daoud Sie
    • , Liz-Anne Lewsley
    • , Aishah Hanif
    • , Cheryl Wilson
    • , Suzanne Dowson
    • , Rosalind M. Glasspool
    • , Michelle Lockley
    • , Elly Brockbank
    • , Ana Montes
    • , Axel Walther
    • , Sudha Sundar
    • , Richard Edmondson
    • , Geoff D. Hall
    • , Andrew Clamp
    • , Charlie Gourley
    • , Marcia Hall
    • , Christina Fotopoulou
    • , Hani Gabra
    • , James Paul
    • , Anna Supernat
    • , David Millan
    • , Aoisha Hoyle
    • , Gareth Bryson
    • , Craig Nourse
    • , Laura Mincarelli
    • , Luis Navarro Sanchez
    • , Bauke Ylstra
    • , Mercedes Jimenez-Linan
    • , Luiza Moore
    • , Oliver Hofmann
    • , Florian Markowetz
    • , Iain A. McNeish
    •  & James D. Brenton
  • Article |

    Analysis of sequencing data from 249 cancer patients with clinically annotated outcomes to immune checkpoint therapy identifies correlates of treatment response. The results highlight complexity in identifying events that generate an immunoresponsive tumor environment.

    • Diana Miao
    • , Claire A. Margolis
    • , Natalie I. Vokes
    • , David Liu
    • , Amaro Taylor-Weiner
    • , Stephanie M. Wankowicz
    • , Dennis Adeegbe
    • , Daniel Keliher
    • , Bastian Schilling
    • , Adam Tracy
    • , Michael Manos
    • , Nicole G. Chau
    • , Glenn J. Hanna
    • , Paz Polak
    • , Scott J. Rodig
    • , Sabina Signoretti
    • , Lynette M. Sholl
    • , Jeffrey A. Engelman
    • , Gad Getz
    • , Pasi A. Jänne
    • , Robert I. Haddad
    • , Toni K. Choueiri
    • , David A. Barbie
    • , Rizwan Haq
    • , Mark M. Awad
    • , Dirk Schadendorf
    • , F. Stephen Hodi
    • , Joaquim Bellmunt
    • , Kwok-Kin Wong
    • , Peter Hammerman
    •  & Eliezer M. Van Allen
  • Article | | open

    Sequencing and de novo assembly of the maize W22 reference genome enable accurate placement of Mutator (Mu) and Dissociation (Ds) transposable element insertions, providing a foundation for maize functional genomics and transposon biology.

    • Nathan M. Springer
    • , Sarah N. Anderson
    • , Carson M. Andorf
    • , Kevin R. Ahern
    • , Fang Bai
    • , Omer Barad
    • , W. Brad Barbazuk
    • , Hank W. Bass
    • , Kobi Baruch
    • , Gil Ben-Zvi
    • , Edward S. Buckler
    • , Robert Bukowski
    • , Michael S. Campbell
    • , Ethalinda K. S. Cannon
    • , Paul Chomet
    • , R. Kelly Dawe
    • , Ruth Davenport
    • , Hugo K. Dooner
    • , Limei He Du
    • , Chunguang Du
    • , Katherine A. Easterling
    • , Christine Gault
    • , Jiahn-Chou Guan
    • , Charles T. Hunter
    • , Georg Jander
    • , Yinping Jiao
    • , Karen E. Koch
    • , Guy Kol
    • , Tobias G. Köllner
    • , Toru Kudo
    • , Qing Li
    • , Fei Lu
    • , Dustin Mayfield-Jones
    • , Wenbin Mei
    • , Donald R. McCarty
    • , Jaclyn M. Noshay
    • , John L. Portwood II
    • , Gil Ronen
    • , A. Mark Settles
    • , Doron Shem-Tov
    • , Jinghua Shi
    • , Ilya Soifer
    • , Joshua C. Stein
    • , Michelle C. Stitzer
    • , Masaharu Suzuki
    • , Daniel L. Vera
    • , Erik Vollbrecht
    • , Julia T. Vrebalov
    • , Doreen Ware
    • , Sharon Wei
    • , Kokulapalan Wimalanathan
    • , Margaret R. Woodhouse
    • , Wenwei Xiong
    •  & Thomas P. Brutnell
  • Article | | open

    The de novo genome assembly of maize line Mo17 and comparative analysis with other sequenced maize lines show extensive gene-order variations. This study provides insights into maize evolution and has implications for improving maize hybrid lines.

    • Silong Sun
    • , Yingsi Zhou
    • , Jian Chen
    • , Junpeng Shi
    • , Haiming Zhao
    • , Hainan Zhao
    • , Weibin Song
    • , Mei Zhang
    • , Yang Cui
    • , Xiaomei Dong
    • , Han Liu
    • , Xuxu Ma
    • , Yinping Jiao
    • , Bo Wang
    • , Xuehong Wei
    • , Joshua C. Stein
    • , Jeff C. Glaubitz
    • , Fei Lu
    • , Guoliang Yu
    • , Chengzhi Liang
    • , Kevin Fengler
    • , Bailin Li
    • , Antoni Rafalski
    • , Patrick S. Schnable
    • , Doreen H. Ware
    • , Edward S. Buckler
    •  & Jinsheng Lai
  • Article |

    The authors use genome editing and live imaging to visualize physical enhancer–promoter interaction and transcription at the single-cell level in Drosophila embryos. They show that sustained proximity of an enhancer to its target is required for transcription.

    • Hongtao Chen
    • , Michal Levo
    • , Lev Barinov
    • , Miki Fujioka
    • , James B. Jaynes
    •  & Thomas Gregor
  • Article |

    Relatedness disequilibrium regression is a new method for estimating heritability that removes environmental bias by taking advantage of variation in relatedness due to random Mendelian segregation.

    • Alexander I. Young
    • , Michael L. Frigge
    • , Daniel F. Gudbjartsson
    • , Gudmar Thorleifsson
    • , Gyda Bjornsdottir
    • , Patrick Sulem
    • , Gisli Masson
    • , Unnur Thorsteinsdottir
    • , Kari Stefansson
    •  & Augustine Kong

Analysis

  • Analysis |

    Analysis of GTEx, cancer and autism data sets shows that cis-regulatory variation can modify the penetrance of coding variants. Deleterious coding variants on regulatory haplotypes resulting in high expression are enriched in disease cohorts and selected against in general populations.

    • Stephane E. Castel
    • , Alejandra Cervera
    • , Pejman Mohammadi
    • , François Aguet
    • , Ferran Reverter
    • , Aaron Wolman
    • , Roderic Guigo
    • , Ivan Iossifov
    • , Ana Vasileva
    •  & Tuuli Lappalainen
  • Analysis |

    SAIGE (Scalable and Accurate Implementation of GEneralized mixed model) is a generalized mixed model association test that can efficiently analyze large data sets while controlling for unbalanced case-control ratios and sample relatedness, as shown by applying SAIGE to the UK Biobank data for > 1,400 binary phenotypes.

    • Wei Zhou
    • , Jonas B. Nielsen
    • , Lars G. Fritsche
    • , Rounak Dey
    • , Maiken E. Gabrielsen
    • , Brooke N. Wolford
    • , Jonathon LeFaive
    • , Peter VandeHaar
    • , Sarah A. Gagliano
    • , Aliya Gifford
    • , Lisa A. Bastarache
    • , Wei-Qi Wei
    • , Joshua C. Denny
    • , Maoxuan Lin
    • , Kristian Hveem
    • , Hyun Min Kang
    • , Goncalo R. Abecasis
    • , Cristen J. Willer
    •  & Seunggeun Lee

    Collection:

Amendments & Corrections

  • Author Correction |

    • Kerrin S. Small
    • , Marijana Todorčević
    • , Mete Civelek
    • , Julia S. El-Sayed Moustafa
    • , Xiao Wang
    • , Michelle M. Simon
    • , Juan Fernandez-Tajes
    • , Anubha Mahajan
    • , Momoko Horikoshi
    • , Alison Hugill
    • , Craig A. Glastonbury
    • , Lydia Quaye
    • , Matt J. Neville
    • , Siddharth Sethi
    • , Marianne Yon
    • , Calvin Pan
    • , Nam Che
    • , Ana Vinuela
    • , Pei-Chien Tsai
    • , Abhishek Nag
    • , Alfonso Buil
    • , Gudmar Thorleifsson
    • , Avanthi Raghavan
    • , Qiurong Ding
    • , Andrew P. Morris
    • , Jordana T. Bell
    • , Unnur Thorsteinsdottir
    • , Kari Stefansson
    • , Markku Laakso
    • , Ingrid Dahlman
    • , Peter Arner
    • , Anna L. Gloyn
    • , Kiran Musunuru
    • , Aldons J. Lusis
    • , Roger D. Cox
    • , Fredrik Karpe
    •  & Mark I. McCarthy
  • Author Correction |

    • Johannes Waage
    • , Marie Standl
    • , John A. Curtin
    • , Leon E. Jessen
    • , Jonathan Thorsen
    • , Chao Tian
    • , Nathan Schoettler
    • , Carlos Flores
    • , Abdel Abdellaoui
    • , Tarunveer S. Ahluwalia
    • , Alexessander C. Alves
    • , Andre F. S. Amaral
    • , Josep M. Antó
    • , Andreas Arnold
    • , Amalia Barreto-Luis
    • , Hansjörg Baurecht
    • , Catharina E. M. van Beijsterveldt
    • , Eugene R. Bleecker
    • , Sílvia Bonàs-Guarch
    • , Dorret I. Boomsma
    • , Susanne Brix
    • , Supinda Bunyavanich
    • , Esteban G. Burchard
    • , Zhanghua Chen
    • , Ivan Curjuric
    • , Adnan Custovic
    • , Herman T. den Dekker
    • , Shyamali C. Dharmage
    • , Julia Dmitrieva
    • , Liesbeth Duijts
    • , Markus J. Ege
    • , W. James Gauderman
    • , Michel Georges
    • , Christian Gieger
    • , Frank Gilliland
    • , Raquel Granell
    • , Hongsheng Gui
    • , Torben Hansen
    • , Joachim Heinrich
    • , John Henderson
    • , Natalia Hernandez-Pacheco
    • , Patrick Holt
    • , Medea Imboden
    • , Vincent W. V. Jaddoe
    • , Marjo-Riitta Jarvelin
    • , Deborah L. Jarvis
    • , Kamilla K. Jensen
    • , Ingileif Jónsdóttir
    • , Michael Kabesch
    • , Jaakko Kaprio
    • , Ashish Kumar
    • , Young-Ae Lee
    • , Albert M. Levin
    • , Xingnan Li
    • , Fabian Lorenzo-Diaz
    • , Erik Melén
    • , Josep M. Mercader
    • , Deborah A. Meyers
    • , Rachel Myers
    • , Dan L. Nicolae
    • , Ellen A. Nohr
    • , Teemu Palviainen
    • , Lavinia Paternoster
    • , Craig E. Pennell
    • , Göran Pershagen
    • , Maria Pino-Yanes
    • , Nicole M. Probst-Hensch
    • , Franz Rüschendorf
    • , Angela Simpson
    • , Kari Stefansson
    • , Jordi Sunyer
    • , Gardar Sveinbjornsson
    • , Elisabeth Thiering
    • , Philip J. Thompson
    • , Maties Torrent
    • , David Torrents
    • , Joyce Y. Tung
    • , Carol A. Wang
    • , Stephan Weidinger
    • , Scott Weiss
    • , Gonneke Willemsen
    • , L. Keoki Williams
    • , Carole Ober
    • , David A. Hinds
    • , Manuel A. Ferreira
    • , Hans Bisgaard
    • , David P. Strachan
    •  & Klaus Bønnelykke
  • Publisher Correction |

    • Jingjing Chen
    • , Ilaria Guccini
    • , Diletta Di Mitri
    • , Daniela Brina
    • , Ajinkya Revandkar
    • , Manuela Sarti
    • , Emiliano Pasquini
    • , Abdullah Alajati
    • , Sandra Pinton
    • , Marco Losa
    • , Gianluca Civenni
    • , Carlo V. Catapano
    • , Jacopo Sgrignani
    • , Andrea Cavalli
    • , Rocco D’Antuono
    • , John M. Asara
    • , Andrea Morandi
    • , Paola Chiarugi
    • , Sara Crotti
    • , Marco Agostini
    • , Monica Montopoli
    • , Ionica Masgras
    • , Andrea Rasola
    • , Ramon Garcia-Escudero
    • , Nicolas Delaleu
    • , Andrea Rinaldi
    • , Francesco Bertoni
    • , Johann de Bono
    • , Arkaitz Carracedo
    •  & Andrea Alimonti