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Volume 7 Issue 5, May 2004

To understand the brain, we must confront its complexity. Thus efforts to 'scale up' data production in neuroscience are on the rise. In this issue, we present a special focus on this topic, a collection of perspective articles that highlight the use of high-throughput methodologies in neuroscience and discuss their current progress and future challenges. Some of the available database resources are described for those who wish to explore this topic further. This special focus is sponsored by the National Institutes of Health. (pp 425-487)

Volume 7 Issue 5

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Editorial

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Book Review

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News & Views

  • The ephrin subclasses A and B are not thought to interact much with each other's receptors. A study in this issue now shows that ephrin-A5 can signal through the EphB2 receptor, toppling this dogma. The crystal structure of the EphB2–ephrin-A5 complex clarifies the molecular features of this interaction and suggests new hypotheses for the mechanism of ephrin receptor signaling.

    • Elena B Pasquale
    News & Views

  • In a new form of synaptic plasticity, depolarization of Purkinje cells increases the frequency of mini GABAergic IPSCs, via glutamate acting as a retrograde messenger on presynaptic NMDA receptors on the terminals of cerebellar interneurons.

    • Anastassios V Tzingounis
    • Roger A Nicoll
    News & Views

  • A new study shows that the transcription factor Tlx3 specifies glutamatergic phenotype and suppresses GABAergic markers during spinal cord development. Understanding this process could ultimately lead to 'customized' neurons for transplantation.

    • Stewart Anderson
    News & Views

  • The extrastriate body area was first identified because it responds to visual images of human body parts. Now a functional imaging study finds that it also responds to self-produced body movements, even when the moving body part is not visible.

    • Marc Jeannerod
    News & Views
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Introduction

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Sponsors' Foreword

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Perspective

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Databases

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Brief Communication

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Article

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Focus

  • These Perspectives critically appraise high-throughput methods such as proteomics, microarrays and multiple-electrode recording, and evaluate the current and future database resources that such studies require. They are freely available with help from the NIH.

    Focus
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