Abstract
Epidemiological data suggest that cocaine dependence emerges rapidly, and most cocaine addicts meet criteria for dependence within 1–3 years after onset of drug use. Here we show that in rats, environmental stimuli associated with a single cocaine self-administration experience elicit strong cocaine-seeking that persists for up to one year. In contrast, conditioned stimuli that were associated with a highly palatable non-drug reinforcer elicited modest behavioral responses that extinguished within 3 months.
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Acknowledgements
Supported by NIH/NIDA grants DA07348 and DA08348 (F.W.). This is manuscript number 15943-NP from The Scripps Research Institute. The authors thank C. Lorentz, N. Stuempfig and J. Simms for technical assistance, as well as C.V. Dayas and M. Arends for assistance with the preparation of the manuscript.
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Ciccocioppo, R., Martin-Fardon, R. & Weiss, F. Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking. Nat Neurosci 7, 495–496 (2004). https://doi.org/10.1038/nn1219
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DOI: https://doi.org/10.1038/nn1219
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