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Proteomics in postgenomic neuroscience: the end of the beginning

Nature Neuroscience volume 7, pages 440–445 (2004)Cite this article

Abstract

Proteomics is complementary to genomic approaches anchored in DNA and RNA. Global characterization of proteins is providing new insights into general biological structures as well as synapses, receptor complexes and other neuronal and glial features. Current challenges for proteomics of the nervous system include problems relating to sample preparation, brain complexity, limited databases and informatics tools. The combination of proteomics with other global functional genomic approaches at the levels of genome and transcriptome, together with network biology, will provide important bridges between genes, physiology and pathology.

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Figure 1: Strategies for mass spectrometry (MS)-based proteomic analysis.

Ivelisse Robles

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Acknowledgements

We thank J.V. Turner for secretarial assistance and L. Yu for assistance with illustrations. J.C. and S.G.N.G. are supported by the Wellcome Trust and Genes to Cognition program.

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  1. Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK

    Jyoti Choudhary & Seth G N Grant

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Correspondence to Seth G N Grant.

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Choudhary, J., Grant, S. Proteomics in postgenomic neuroscience: the end of the beginning. Nat Neurosci 7, 440–445 (2004). https://doi.org/10.1038/nn1240

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