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Sasaki et al. reveal that the dentate gyrus not only performs pattern separation but also has a direct role in organizing memory-guided behavior by coordinating the planning of future actions.
Using a genetic approach, Wang et al. demonstrate an essential function for m6A mRNA modification in promoting neural stem cell proliferation and reveal interactions between m6A and histone modification as a novel gene regulatory mechanism.
fMRI activity in human entorhinal cortex is modulated by eye-movement direction with 60° periodicity, implicating a grid cell-like code in mapping visual space. This suggests a role for entorhinal grid coding in cognition beyond spatial navigation.
In the Drosophila visual system, T4 is the first cell type in the ON pathway to exhibit directionally selective signals. This directional selectivity originates from simple integration of spatially offset fast excitatory and slow inhibitory inputs.
The brain is a complex biological machine that results from the birth, migration and differentiation of neurons. This paper reports that Vps15 enables the migration and survival of neurons, and implicates the gene in neurodevelopmental disease.
The authors show that human entorhinal cortex supports a grid cell-like representation of visual space. This visual grid pattern is stably anchored to the external visual world in a fashion analogous to rodent grid representations of navigable space.
In mice, stress-induced priming of glutamate synapses in the PVN can be transmitted through social interactions. This requires PVN CRH neuron activation in both of the interacting mice and release of an alarm pheromone from the stressed mouse.
Pathological TDP-43 protein aggregates are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43 pathology alters the morphology of nuclear pore complexes and cause deficits in nucleocytoplasmic transport.
Polanía, Nitsche and Ruff summarize the state of non-invasive brain stimulation research in humans, discuss some current debates about properties and limitations of these methods, and give recommendations for how these challenges may be addressed.
Assessing person-level human brain maps across 18 fMRI studies, the authors identify separable representations of pain, cognitive control, and negative emotion in the medial frontal cortex that generalize across different studies and tasks.