Reviews & Analysis

Polyelectrolytes are a class of macromolecules containing charged groups. Here the authors review properties and functions of metallo-polyelectrolytes to shed light on how to harness fundamental physiochemical properties for applications in biomedical sciences and advanced materials.

A variety of directional electronic transport phenomena can occur in materials with broken inversion-symmetry. Here, Tokura and Nagaosa review the underlying mechanisms and emergent phenomena of nonreciprocal responses in noncentrosymmetric quantum materials.

Research and debate are intensifying on complementing CO₂ emissions reductions with hypothetical climate geoengineering techniques. Here, the authors assess their potentials, uncertainties and risks, and show that they cannot yet be relied on to significantly contribute to meeting the Paris Agreement temperature goals.

Understanding the contributions of extrinsic and intrinsic factors on cancer risk is fundamental in determining the intervention and prevention strategies to tackle cancer. Here the authors provide a review of the different factors impacting cancer risk and discuss the limitations of different approaches in evaluating the relative contributions of these factors.

Active matter systems are made up of self-driven components which extract energy from their surroundings to generate mechanical work. Here the authors review the subfield of active nematics and provide a comparison between theoretical findings and the corresponding experimental realisations.

Accelerated global warming in the Arctic might have profound impacts on mid-latitude weather particularly in winter, although the evidence for an effect also in summer is also growing. Here Coumou et al. show that these interactions could lead to more persistent hot-dry extremes in mid-latitudes.

Gut microbial metabolites are known to impact many physiological processes of the host and play a critical role in immune-homeostasis. Here the authors review our current understanding and appreciation of the importance of microbially derived tryptophan catabolites during both health and disease.

Targeting DNA repair-deficient tumors is one of the most promising therapeutic strategies in cancer research; however, accurately predicting which tumors will respond can be a challenge. Here the authors present a review of the current state of knowledge in DNA repair deficiency across human cancers.

Inflammation is a component of many chronic inflammatory diseases and yet it is understudied in medicine. Here, the authors review novel insights in to inflammation and how impairment of its resolution can lead to diseases.

Indigenous peoples are still underrepresented in genetic research. Here, the authors propose an ethical framework consisting of six major principles that encourages researchers and Indigenous communities to build strong and equal partnerships to increase trust, engagement and diversity in genomic studies.

Synthetic biology often views the organism as a chassis into which a circuit can be inserted. Here the authors explore the idea of the organism as a core aspect of design, aiding researchers in navigating the genetic space opened up by SCRaMbLE.

Eruptive styles at a single volcano may transition from explosive to effusive behaviour (or vice versa) at any given time. This review examines the underlying controls on eruptive styles such as magma viscosity, degassing and conduit geometry at volcanoes with silicic compositions.

Excitons, quasi-particles of tightly bound electron-hole pairs, dominate the optical response of atomically thin transition metal dichalcogenides. Here, the authors review strong light-matter coupling in two-dimensional semiconductors arising from confined excitons interacting with trapped photons or localized plasmons.

Metal dissolution from atmospheric aerosol deposition plays an important role in enhancing and inhibiting phytoplankton growth and community structure. Here, the authors review the impacts of trace metal leaching from natural and anthropogenic aerosols on marine microorganisms over short and long timescales.

Understudied in the Antarctic system are the subsurface interfaces between ice-sheet, ocean and geological substrate. Here, the authors review our understanding of these components and propose new avenues of holistic dynamic modeling to achieve a unified understanding of past, present and future polar climate.

Temporary association of metabolic enzymes is generally assumed to facilitate substrate channelling within the complex. In this review, Lee Sweetlove and Alisdair Fernie outline the nature and functional consequence of organising enzymes into assemblies, and discuss applications within the natural world and synthetic biology.

Rydberg molecules have been extensively studied both theoretically and experimentally. Here the authors review the recent developments in the study of various types of Rydberg molecules and their potential for future applications in spectroscopy, sensing and quantum information.

CRISPR has rapidly become an indispensable tool for biological research. Here Mazhar Adli reviews the current toolbox for editing and manipulating the genome and looks toward future developments in this fast moving field.

Estimating the magnitude of radiative and non-radiative feedbacks is key for understanding the climate dynamics of polar regions. Here the authors propose an inclusive methodology to quantify the influence of all those feedbacks, stimulating more systematic analyses in observational and model ensembles.