Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Solid hydrogen has increasingly hindered rotation under high pressure, but the effect on spin isomer populations had not been directly probed. Here the authors measure NMR spectra of solid hydrogen up to the megabar, and observe the crossover to a spin 1/2 dipolar system above 70 GPa where distinction between ortho and para spin isomers is lost.
Gas bubbles forming on the surface of an electrode, a phenomenon common to several industrial electrolytic processes, are usually perceived as inert, passivating entities. Here, the authors show that that this general assumption does not hold for gas bubbles masking anodes operating in water.
A principle of neuroanatomy, namely diffuse connectivity, is modeled using a large-scale network of corticothalamic neural masses. We demonstrate that increases in diffuse coupling transition the system through a quasi-critical regime, which coincides with known signatures of complex adaptive brain dynamics, and model fits to human imaging data orient task states to higher levels of diffusivity, consistent with the influence of arousal systems.
Hitherto, only circularly polarized antiferromagnetic (AFM) spin-waves (SWs) were expected to convey spin-information. Here, the authors present persistent spin-transport over long distances in the easy-plane AFM phase of hematite, α-Fe2O3, via linearly polarized SW pairs with ultra-low damping.
Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherapy.
Mixed-halide perovskites are of interest for photovoltaic devices, but light-induced halide segregation obstructs bandgap tuning and is not fully understood. Here the authors study the effects of strain and iodide/bromide ratio on light-induced halide segregation in mixed-halide perovskites.
The differential adhesion hypothesis is proposed to play a role during epithelial tissue morphogenesis but it has remained unclear. Here, the authors identify the Toll-1 receptor as a differentially expressed adhesion molecule that maintains lineage restriction boundaries in the Drosophila epidermal epithelium.
Responsive soft materials which can exhibit various three-dimensional (3D) shapes under the same stimulus are desirable for applications in adaptive and reconfigurable soft robots. Here, the authors report a laser rewritable magnetic composite film, whose responsive shape-morphing behaviors induced by a magnetic field can be digitally and repeatedly reprogrammed by a facile method of direct laser writing.
Varicella-zoster virus (VZV) establishes lifelong neuronal latency in humans. Here, Ouwendijk and Depledge et al. identify a fusion transcript, VLT-ORF63, which is expressed during lytic and latent infection, and demonstrate a role for the translated fusion protein in induction of lytic gene expression from latent VZV genomes.
The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the genetic architecture underlying biomarker variation.
Iron minerals trap carbon in permafrost, preventing microbial degradation and release to the atmosphere as CO2, but the stability of this carbon as permafrost thaws is unclear. Here the authors use nanoscale analyses to show that thaw conditions stimulate Fe-reducing bacteria that trigger carbon release.
The uptake of hydrophobic molecules by bacterial FadL channels is implicated in quorum sensing, interactions with eukaryotic hosts and biodegradation of many pollutants. Insights into monoaromatic hydrocarbon uptake by TodX and CymD channels suggest that all FadL channels mediate substrate uptake via lateral diffusion.
The effects of pesticides on individual species could propagate into additional community-wide and ecosystem-level effects. Here the authors use a mesocosm experiment to test how a diverse array of herbicides and insecticides disrupt aquatic community structure and ecosystem function.
The ventromedial hypothalamus (VMH) serves as a satiety center in the brain, however, the neural circuits involved are incompletely understood. Here, the authors decipher a neural circuit from VMH to the paraventricular thalamus that suppresses food intake.
Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss of RANK signaling in tumor cells drives a T cell-dependent anti-tumor response in preclinical models.
Multiple whole-genome alignment is a challenging problem in bioinformatics, especially when computational resources are limited. Here the authors present SibeliaZ, an algorithm and software based on analysis of de Bruijn graphs, which provides improved computational efficiency and scalability.
Therapeutic angiogenesis has the potential of inducing and maintaining new blood vessels and thus improving outcomes in patients with ischemic disorders. Mannosamine functions as an endothelial cell mitogen/survival factor through activation of stress pathways and might be useful to protect and regenerate the vascular endothelium in a variety of disorders.
Unlike traditional chiral metal complexes, which typically contain chiral ligands, in chiral-at-metal complexes chirality originates from a stereogenic metal center bound to achiral ligands. Herein, the authors use an unsymmetric tridentate ligand to construct a Werner-type tetrahedral chiral-at-zinc complex which displays high configurational stability and catalyzes an oxa-Diels-Alder reaction with high yield and enantioselectivity.
C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.
Nanopore sequencing (ONT) has been used in SARS-CoV-2 studies, however adoption of ONT for SARS-CoV-2 surveillance has been limited due to common concerns around sequencing accuracy. Here, the authors perform a comprehensive evaluation of ONT analytical performance on 157 matched SARS-CoV-2-positive patient specimens and synthetic RNA controls.