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How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.
Here, the authors perform spectroscopic investigations of individual Formamidinium lead iodide nanocrystals, demonstrate single-photon emission and unravel the mechanisms of carrier–phonon interactions. These results will guide the development of next-generation devices for photovoltaics and quantum technologies.
SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.
Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.
In general the computational requirements for simulating quantum systems scale exponentially but in some cases it is possible to formulate more efficient schemes. Here the authors present an efficient approach to calculate non-Markovian quantum dynamics using matrix product operator methods.
Digital traces of our lives have the potential to allow insights into collective behaviors. Here, the authors cluster consumers by their credit card purchase sequences and discover five distinct groups, within which individuals also share similar mobility and demographic attributes.
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.
High temperature perpendicular ferroelectricity in nano thin films is crucial for miniaturization of electronic devices. Here the authors show the presence of stable and switchable out-of-plane ferroelectricity in tetragonal BiFeO3 thin films at the two-dimensional limit and 370% tunneling electroresistance in ferroelectric tunnel junctions.
The competition between Kondo correlations and magnetic ordering in heavy fermion materials leads to emergent physics that is not fully understood. Seiro et al. show inter-site Kondo correlations only dominate over local ones at temperatures well below the single-ion Kondo temperature but this is a prerequisite for quantum critical behavior.
Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis.
Heat transport in ultrathin metal layers is important for potential applications in optical‐magnetic switching, but difficult to access experimentally. Here, the authors use ultrafast X‐ray diffraction to directly probe and explain unexpected time‐dependent transport behavior in Au–Ni nanolayers.
Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.
To date, the precise localisation of ligands and adhesion proteins are determined in two parallel characterization setups. Here, the authors report a self-assembled monolayer chemistry for indium tin oxide surfaces allowing single molecule localisation microscopy (SMLM) imaging of ligands and adhesion proteins in a single experiment.
The ionosphere can give rise to irregularities that can interfere with radio communication, navigation and satellite systems. Here the authors present unique observations from the Arecibo Radio Observatory in Puerto Rico to reveal the existence of plasma irregularities occur in the mid-latitude F-region.
The ubiquitin-like modifier FAT10 is composed of two ubiquitin-like domains (UBDs). Here the authors present the FAT10 UBD structures and show that the unstructured FAT10 N-terminal heptapeptide together with the poor stability of FAT10 facilitate the rapid proteasomal targeting of FAT10 along with its substrates.
Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidate for this devastating disease.
Soil thickness is a key parameter in earth system models, yet how it varies spatially at catchment scales is largely unknown due to measurement challenges. Here, the authors show that a continuous field of thicknesses can be predicted using high-resolution topography and a few soil thickness measurements.
Two-dimensional (2D) bismuth oxyselenide crystals with suitable electronic band-gap and ultrahigh carrier mobility enable near-infrared photodetection. Here, the authors report an infrared photodetector based on 2D-bismuth oxyselenide with high responsivity, ultrafast photoresponse of ~ 1 ps at room temperature and a detectable frequency limit of up to 500 GHz.
Artificial nanostructures designed to simulate models of materials such as graphene provide insights into the material physics but can also have practical advantages. Du et al. create low-disorder artificial graphene devices, and present evidence of terahertz spin-exciton modes and large Coulomb interactions.
Upconversion nanoparticles offer the potential for deep tissue biological imaging. Here, Chen et al. develop super resolution optical imaging in the near-infrared for imaging with sub-50 nm resolution through almost 100 microns of tissue.