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Synthetic circuits that can record in vivo signaling networks is critical in elucidating developmental process. Here, the authors describe the engineering and application of synthetic in vivo recorders with different promoters that can drive spatiotemporally-specific integrase switching during lateral root initiation.
Approaches for temporal analysis and quantitative characterisation of single cell morphology and dynamics remain in high demand. Here authors present CellPhe, a pattern recognition toolkit for the unbiased characterisation of cellular phenotypes within time-lapse videos.
C–N bond cross-coupling is fundamental in organic chemistry, but the readily available organic fluorides are unsuitable as coupling substrates. Here, we realize defluorinative cross-coupling with amines via a silylboronate-mediated strategy.
In our gut, oxalate-degrading bacteria absorb oxalate, a causative substance for kidney stone formation, and reduce our health risk. In this work, the authors report the structure of the oxalate transporter responsible for this process and how the protein works.
J-aggregation, is an effective strategy to extend the wavelength of organic NIR-II fluorescence dyes but weak intermolecular interactions often lead to decomposition of the aggregates in biological environment. Here, the authors demonstrate a series of activatable quinazoline derivatives which can self-assemble in vivo into highly stable NIR-IIJ-aggregates.
This work reveals the diversity and extent of human antibody specificities in Chagas disease and provides a wealth of well-defined antigenic markers for diagnosis and development of serological applications for this neglected infectious disease.
Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells. Fbf1 ablation reduces senescence and associated health decline in mice, highlighting cilia as a promising senotherapy target.
Molecular rearrangements are ubiquitous in modern synthetic chemistry, providing a powerful strategy to arrive at complex structures in an atom- and step-economic process. Here, the authors disclose a Mn(I)- catalyzed sigmatropic rearrangement of β, γ-unsaturated alcohols via C-C σ-bond activation to site-selectively reorganize carbon skeletons.
Cl-redox reactions cannot be fully exploited in batteries because of the Cl2 gas evolution. Here, reversible high-energy interhalogen reactions are demonstrated by using a iodine-based cathode in combination with a Zn anode and a Cl-containing aqueous electrolyte solution.
Liquid-liquid phase separation offer a strategy for targeting biomaterial scaffolds, but controlling assembly to form functional materials is challenging. Here, the authors transform native proteins into amyloid fibres for assembly, and use the materials as a gastric ulcer protective agent.
Here, the authors utilise a combination of quasi-spherical theory and Jahn-Teller distortion to enhance the piezoelectric response of molecular metal halides, and the resulting piezoelectric energy harvesters exhibit superior power densities to the best-reported molecular hybrid energy harvesters.
Patient samples are often available in limited amounts, restricting the number of possible omics analyses. Here the authors present MONTE, a workflow that enables serial HLA-I and HLA-II immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome data collection from patient samples.
Fischer-Tropsch synthesis is challenged by the trade-off between enhancing C-C coupling and suppressing further hydrogenation of olefins. Here the authors break this challenge by developing a universal strategy to synthesis extra-heavy olefins from carbon monoxide and water via the sustained release of hydrogen and selective extraction of olefins.
Origami-inspired engineering has enabled intelligent materials and structures to react to environments, yet a complete sense-decide-act autonomous loop is still challenging. Yan et al. introduce autonomous origami robots by embedding sensing, computing, and actuating in compliant, conductive materials.
Preparation of functionalized analogues of 1,2-benzdiyne, from heavily substituted as well as benzofused scaffolds, is challenging. Here, the authors develop an array of 3-sulfonyloxyaryl(mesityl)iodonium triflates as 1,2-benzdiyne precursors, triggered from ortho-deprotonative elimination.
The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying human development and disease.
Spatial visualization of metabolites in tissues via mass spectrometry imaging can be prone to user perception bias. Here, the authors report the computational framework moleculaR that introduces probabilistic data-dependent molecular mapping of nonrandom spatial patterns of metabolite signals.
The optical quality of large-area transition metal dichalcogenide (TMD) monolayers is usually limited by surface defects and inhomogeneities. Here, the authors report a method based on 1-dodecanol encapsulation to improve the optical properties of TMD monolayers over mm-scale, enabling the fabrication of an array of polariton photonic crystal cavities.
This study offers molecular insight into the sialidase and fucosidase decapping apparatus that initiates growth on mucin and promotes nutrient sharing by the dedicated mucolytic symbiont Akkermansia muciniphila with the mucus-associated microbiota.
Liver cirrhosis is characterised by extensive fibrosis of the liver, and understanding the underpinning immunological processes is important in designing intervention. Here authors show that Mucosal-Associated Invariant T cells are instrumental to controlling the balance between profibrogenic and restorative macrophages and inhibiting their activation might reverse liver fibrosis.