Browse Articles

  • Article | | open

    Electronegativity is a fundamental concept in chemistry; however it is an elusive quantity to evaluate experimentally. Here, the authors estimate the Pauling electronegativity of individual atoms on a surface via atomic force microscopy using a variety of chemically reactive tips.

    • Jo Onoda
    • , Martin Ondráček
    • , Pavel Jelínek
    •  & Yoshiaki Sugimoto
  • Article | | open

    As alkali-ion battery anodes, metal oxide nanomaterials suffer from severe structural degradation after charging/discharging cycling. Here the authors develop two-dimensional holey nanosheet anodes which display minimal structural changes during electrochemical operation.

    • Lele Peng
    • , Pan Xiong
    • , Lu Ma
    • , Yifei Yuan
    • , Yue Zhu
    • , Dahong Chen
    • , Xiangyi Luo
    • , Jun Lu
    • , Khalil Amine
    •  & Guihua Yu
  • Article | | open

    Unravelling the fundamental mechanisms of emergence of complex behaviour is key to understanding living systems. Here, the authors provide a simple experimental platform to investigate and control a rich set of complex phenomena, akin to those seen in living organisms, from a nonliving system of colloidal nanoparticles.

    • Serim Ilday
    • , Ghaith Makey
    • , Gursoy B. Akguc
    • , Özgün Yavuz
    • , Onur Tokel
    • , Ihor Pavlov
    • , Oguz Gülseren
    •  & F. Ömer Ilday
  • Article | | open

    Quantum communications will be used to transmit entanglement and secure keys, but it is important to estimate their optimal transfer rates. Here the authors compute the fundamental limit of repeaterless quantum communications for the most relevant practical scenario.

    • Stefano Pirandola
    • , Riccardo Laurenza
    • , Carlo Ottaviani
    •  & Leonardo Banchi
  • Article | | open

    Hyperpolarized magnetic resonance imaging can enhance imaging contrast by orders of magnitude, but applications are limited by the thermal relaxation of hyperpolarized states. Here, Waddington et al. demonstrate the on-demand hyperpolarization of hydrogen spins through the Overhauser effect with nanodiamonds.

    • David E. J. Waddington
    • , Mathieu Sarracanie
    • , Huiliang Zhang
    • , Najat Salameh
    • , David R. Glenn
    • , Ewa Rej
    • , Torsten Gaebel
    • , Thomas Boele
    • , Ronald L. Walsworth
    • , David J. Reilly
    •  & Matthew S. Rosen
  • Article | | open

    Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.

    • Xiangxi Wang
    • , Shi-Hua Li
    • , Ling Zhu
    • , Qing-Gong Nian
    • , Shuai Yuan
    • , Qiang Gao
    • , Zhongyu Hu
    • , Qing Ye
    • , Xiao-Feng Li
    • , Dong-Yang Xie
    • , Neil Shaw
    • , Junzhi Wang
    • , Thomas S. Walter
    • , Juha T. Huiskonen
    • , Elizabeth E. Fry
    • , Cheng-Feng Qin
    • , David I. Stuart
    •  & Zihe Rao
  • Article | | open

    Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xie et al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.

    • Feng Xie
    • , Ke Jin
    • , Li Shao
    • , Yao Fan
    • , Yifei Tu
    • , Yihao Li
    • , Bin Yang
    • , Hans van Dam
    • , Peter ten Dijke
    • , Honglei Weng
    • , Steven Dooley
    • , Shuai Wang
    • , Junling Jia
    • , Jin Jin
    • , Fangfang Zhou
    •  & Long Zhang
  • Article | | open

    Silver compounds have long been known to possess exceptional solid-state conductivity. Here the authors present silver closo-boranes in which facile Ag+ migration occurs, leading to exceptionally high ion conductivities and potential utility in silver nanowire production and photocatalysis due to their semiconductivity.

    • Mark Paskevicius
    • , Bjarne R. S. Hansen
    • , Mathias Jørgensen
    • , Bo Richter
    •  & Torben R. Jensen
  • Article | | open

    Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.

    • Ophelia S. Venturelli
    • , Mika Tei
    • , Stefan Bauer
    • , Leanne Jade G. Chan
    • , Christopher J. Petzold
    •  & Adam P Arkin
  • Article | | open

    The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances SC proliferation and differentiation.

    • Yaqi Deng
    • , Lai Man Natalie Wu
    • , Shujun Bai
    • , Chuntao Zhao
    • , Haibo Wang
    • , Jincheng Wang
    • , Lingli Xu
    • , Masahide Sakabe
    • , Wenhao Zhou
    • , Mei Xin
    •  & Q. Richard Lu
  • Article | | open

    Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

    • Anne E. Justice
    • , Thomas W. Winkler
    • , Mary F. Feitosa
    • , Misa Graff
    • , Virginia A. Fisher
    • , Kristin Young
    • , Llilda Barata
    • , Xuan Deng
    • , Jacek Czajkowski
    • , David Hadley
    • , Julius S. Ngwa
    • , Tarunveer S. Ahluwalia
    • , Audrey Y. Chu
    • , Nancy L. Heard-Costa
    • , Elise Lim
    • , Jeremiah Perez
    • , John D. Eicher
    • , Zoltán Kutalik
    • , Luting Xue
    • , Anubha Mahajan
    • , Frida Renström
    • , Joseph Wu
    • , Qibin Qi
    • , Shafqat Ahmad
    • , Tamuno Alfred
    • , Najaf Amin
    • , Lawrence F. Bielak
    • , Amelie Bonnefond
    • , Jennifer Bragg
    • , Gemma Cadby
    • , Martina Chittani
    • , Scott Coggeshall
    • , Tanguy Corre
    • , Nese Direk
    • , Joel Eriksson
    • , Krista Fischer
    • , Mathias Gorski
    • , Marie Neergaard Harder
    • , Momoko Horikoshi
    • , Tao Huang
    • , Jennifer E. Huffman
    • , Anne U. Jackson
    • , Johanne Marie Justesen
    • , Stavroula Kanoni
    • , Leena Kinnunen
    • , Marcus E. Kleber
    • , Pirjo Komulainen
    • , Meena Kumari
    • , Unhee Lim
    • , Jian'an Luan
    • , Leo-Pekka Lyytikäinen
    • , Massimo Mangino
    • , Ani Manichaikul
    • , Jonathan Marten
    • , Rita P. S. Middelberg
    • , Martina Müller-Nurasyid
    • , Pau Navarro
    • , Louis Pérusse
    • , Natalia Pervjakova
    • , Cinzia Sarti
    • , Albert Vernon Smith
    • , Jennifer A. Smith
    • , Alena Stančáková
    • , Rona J. Strawbridge
    • , Heather M. Stringham
    • , Yun Ju Sung
    • , Toshiko Tanaka
    • , Alexander Teumer
    • , Stella Trompet
    • , Sander W. van der Laan
    • , Peter J. van der Most
    • , Jana V. Van Vliet-Ostaptchouk
    • , Sailaja L. Vedantam
    • , Niek Verweij
    • , Jacqueline M. Vink
    • , Veronique Vitart
    • , Ying Wu
    • , Loic Yengo
    • , Weihua Zhang
    • , Jing Hua Zhao
    • , Martina E. Zimmermann
    • , Niha Zubair
    • , Gonçalo R. Abecasis
    • , Linda S. Adair
    • , Saima Afaq
    • , Uzma Afzal
    • , Stephan J. L. Bakker
    • , Traci M. Bartz
    • , John Beilby
    • , Richard N. Bergman
    • , Sven Bergmann
    • , Reiner Biffar
    • , John Blangero
    • , Eric Boerwinkle
    • , Lori L. Bonnycastle
    • , Erwin Bottinger
    • , Daniele Braga
    • , Brendan M. Buckley
    • , Steve Buyske
    • , Harry Campbell
    • , Jaspal S. Kooner
    • , Yii-DerIda Chen
    • , Claes Ohlsson
    • , Morris A. Swertz
    • , Georg Homuth
    • , Barbara Thorand
    • , Lars Lind
    • , Jessica Tyrrell
    • , Annette Peters
    • , Harold Snieder
    • , Bruce M. Psaty
    • , Erik Ingelsson
    • , John-Olov Jansson
    • , M Carola Zillikens
    • , David R. Weir
    • , Mika Kivimaki
    • , Sarah Wild
    • , Graciela E. Delgado
    • , Tamara B. Harris
    • , Maija Hassinen
    • , Ken K. Ong
    • , Dan Mellström
    • , Damiano Baldassarre
    • , Charlotta Pisinger
    • , Ozren Polasek
    • , Albertine J. Oldehinkel
    • , Kirsti Kvaløy
    • , Jaakko Tuomilehto
    • , Igor Rudan
    • , Alan F. Wright
    • , Sandosh Padmanabhan
    • , Barbara McKnight
    • , Nanette R. Lee
    • , Ian Ford
    • , Markku Laakso
    • , Liesbeth Vandenput
    • , Karin Leander
    • , David P. Strachan
    • , Kai Savonen
    • , Winfried März
    • , Marie-Claude Vohl
    • , Catharina A. Hartman
    • , Anna L. Eriksson
    • , Tuomo Rankinen
    • , Ilja M. Nolte
    • , Robert Luben
    • , Stephanie A. Bien
    • , Gitta Lubke
    • , Gudny Eiriksdottir
    • , Joseph Hung
    • , Carsten A. Böger
    • , Timo A. Lakka
    • , Caroline S. Fox
    • , Ulrike Peters
    • , Jessica D. Faul
    • , Eco J. C. de Geus
    • , Hans- Jörgen Grabe
    • , Hester M. den Ruijter
    • , Timothy M. Frayling
    • , Marjo-Riitta Jarvelin
    • , P Eline Slagboom
    • , Elena Tremoli
    • , Heikki A. Koistinen
    • , Min A. Jhun
    • , Rajesh Rawal
    • , Oddgeir L. Holmen
    • , Harald Grallert
    • , Andrew Wong
    • , Gerard Pasterkamp
    • , Konstantin Strauch
    • , Claudia Langenberg
    • , Tim D. Spector
    • , Bamidele O. Tayo
    • , Iris M. Heid
    • , Thorkild I. A. Sørensen
    • , Cristina Menni
    • , Marie Loh
    • , Henrik Vestergaard
    • , Naveed Sattar
    • , James F. Wilson
    • , Penny Gordon-Larsen
    • , Pim van der Harst
    • , Philippe Froguel
    • , Andrew P. Morris
    • , Caroline Hayward
    • , Claudia Schurmann
    • , Anders Hamsten
    • , Reija Männikkö
    • , Narisu Narisu
    • , Stefania Bandinelli
    • , Nicholas J. Wareham
    • , Andre G. Uitterlinden
    • , Diana Kuh
    • , Sara Lupoli
    • , AW (Bill) Musk
    • , Dorret I. Boomsma
    • , David Schlessinger
    • , Saskia Haitjema
    • , Jan A. Staessen
    • , Kent D. Taylor
    • , Nicola Glorioso
    • , Treva Rice
    • , Peter S. Chines
    • , Francis S. Collins
    • , David J. Hunter
    • , Paul W. Franks
    • , Torben Hansen
    • , Matthias Nauck
    • , Laura J. Rasmussen-Torvik
    • , D. C. Rao
    • , Cornelia M. van Duijn
    • , George Dedoussis
    • , John C. Chambers
    • , Ruth J. F. Loos
    • , L Adrienne Cupples
    • , Niels Grarup
    • , Blair H. Smith
    • , Joanne E. Curran
    • , Grant W. Montgomery
    • , Tanja B. Grammer
    • , Dorothee Thuillier
    • , Melanie Waldenberger
    • , Richard S. Cooper
    • , J Wouter Jukema
    • , Lynne J. Hocking
    • , Beverley Balkau
    • , Gérard Waeber
    • , Tõnu Esko
    • , Mark A. Sarzynski
    • , Anton J. M. de Craen
    • , Bengt Sennblad
    • , Luigi Ferrucci
    • , Peter Vollenweider
    • , Inês Barroso
    • , Gert J. de Borst
    • , Jouke Jan Hottenga
    • , Robert A. Scott
    • , Lenore J. Launer
    • , Göran Hallmans
    • , Loic Le Marchand
    • , Sharon L. R. Kardia
    • , Marit E. Jørgensen
    • , Bernhard K. Krämer
    • , Jonathan Marchini
    • , Christopher A. Haiman
    • , Alan L. James
    • , Marten A. Siemelink
    • , Lyle J. Palmer
    • , Kari E. North
    • , Charles Kooperberg
    • , Bruna Gigante
    • , Nicholas D. Hastie
    • , Mette Hollensted
    • , Dena Hernandez
    • , Lynda M. Rose
    • , Tuomas O. Kilpeläinen
    • , Ingrid B. Borecki
    • , Rainer Rauramaa
    • , Lu Qi
    • , Olli T. Raitakari
    • , Panagiotis Deloukas
    • , David J. Porteous
    • , R. G. J. Westendorp
    • , Wei Zhao
    • , Joel N. Hirschhorn
    • , Magnus Karlsson
    • , Terho Lehtimäki
    • , Henry Völzke
    • , Andrew D. Johnson
    • , David J. Stott
    • , Andrew C. Heath
    • , Allan Linneberg
    • , Markus Juonala
    • , John B. Whitfield
    • , Bruce H. R. Wolffenbuttel
    • , Terrence Forrester
    • , Ching-Ti Liu
    • , Karl Gertow
    • , Jian Gong
    • , Claude Bouchard
    • , Pedro Marques-Vidal
    • , Amy J. Swift
    • , Vilmundur Gudnason
    • , Paul M. Ridker
    • , Kristian Hveem
    • , Lucia Hindorff
    • , Colin A. McKenzie
    • , Anja Ludolph-Donislawski
    • , Salome Scholtens
    • , Patricia A. Peyser
    • , Ulf de Faire
    • , Mark I. McCarthy
    • , Jie Huang
    • , Nicholas G. Martin
    • , Mika Kähönen
    • , Henning Tiemeier
    • , Oluf Pedersen
    • , Mattias Lorentzon
    • , Serena Sanna
    • , Matthias Olden
    • , Judith M. Vonk
    • , Stephane Lobbens
    • , Andres Metspalu
    • , Cecilia M. Lindgren
    • , Karen L. Mohlke
    • , Nina Hutri-Kähönen
    • , Francesco Cucca
    • , Pamela A. F. Madden
    • , Daniel I. Chasman
    • , Günther Silbernagel
    • , Gonneke Willemsen
    • , Marcel Bruinenberg
    • , Daniele Cusi
    • , Ivana Kolcic
    • , Michael Boehnke
    • , Johanna Kuusisto
    •  & Genovefa Kolovou
  • Article | | open

    Cortical thickness has high heritability estimates and is known to be influenced by genetic factors. Here, Freytag and colleagues show that DNA methylation patterns of peripheral blood monocytes are also correlated with cortical thickness and memory performance in human.

    • Virginie Freytag
    • , Tania Carrillo-Roa
    • , Annette Milnik
    • , Philipp G. Sämann
    • , Vanja Vukojevic
    • , David Coynel
    • , Philippe Demougin
    • , Tobias Egli
    • , Leo Gschwind
    • , Frank Jessen
    • , Eva Loos
    • , Wolfgang Maier
    • , Steffi G. Riedel-Heller
    • , Martin Scherer
    • , Christian Vogler
    • , Michael Wagner
    • , Elisabeth B. Binder
    • , Dominique J. -F. de Quervain
    •  & Andreas Papassotiropoulos
  • Article | | open

    In lithium-ion batteries the interactions between the electrode and electrolyte represent a complex but critical process. Here the authors reveal the dynamic behaviour of interphases driven by conductive carbon through chemical and imaging analyses of a model transition-metal oxide cathode material.

    • Wangda Li
    • , Andrei Dolocan
    • , Pilgun Oh
    • , Hugo Celio
    • , Suhyeon Park
    • , Jaephil Cho
    •  & Arumugam Manthiram
  • Article | | open

    Active fluids consist of self-driven particles that can drive spontaneous flow without the intervention of external forces. Here Woodhouse et al. show how to design logic circuits using this phenomenon in active fluid networks, which could be further exploited for autonomous microfluidic computing.

    • Francis G. Woodhouse
    •  & Jörn Dunkel
  • Article | | open

    Despite recent technological advances, it remains challenging to realize reversible high-areal-capacity lithium metal anodes. Here, the authors demonstrate such an anode by tailoring the top solid electrolyte interphase layer.

    • Hui Wang
    • , Masaki Matsui
    • , Hiroko Kuwata
    • , Hidetoshi Sonoki
    • , Yasuaki Matsuda
    • , Xuefu Shang
    • , Yasuo Takeda
    • , Osamu Yamamoto
    •  & Nobuyuki Imanishi
  • Article | | open

    Epigenetic factors can regulate functional properties of human colorectal cancer stem cells. Here, the authors show that histone demethylases of the KDM3 family activate Wnt signalling in colorectal cancer stem cells by erasing H3K9me2 marks on Wnt target genes and recruiting MLL1 to promote H3K4 methylation.

    • Jiong Li
    • , Bo Yu
    • , Peng Deng
    • , Yingduan Cheng
    • , Yongxin Yu
    • , Kareena Kevork
    • , Sivakumar Ramadoss
    • , Xiangming Ding
    • , Xinmin Li
    •  & Cun-Yu Wang
  • Article | | open

    Simple synthetic routes to polyaromatic hydrocarbons are important due to their applications in organic electronics. Here the authors report a straightforward synthesis of a diverse range of polyaromatic hydrocarbons, via a one-pot oxidative cyclisation and subsequent 1,2-aryl migration.

    • Xuan Zhang
    • , Zhanqiang Xu
    • , Weili Si
    • , Kazuaki Oniwa
    • , Ming Bao
    • , Yoshinori Yamamoto
    •  & Tienan Jin
  • Article | | open

    Vacancies in 2D materials can influence their properties, however controlling their formation remains a challenge. Here the authors show that selective etching of a 3D laminate with in-plane chemical ordering results in formation of MXenes with ordered divacancies, as well as elevated conductance and supercapacitance.

    • Quanzheng Tao
    • , Martin Dahlqvist
    • , Jun Lu
    • , Sankalp Kota
    • , Rahele Meshkian
    • , Joseph Halim
    • , Justinas Palisaitis
    • , Lars Hultman
    • , Michel W. Barsoum
    • , Per O.Å. Persson
    •  & Johanna Rosen
  • Article | | open

    TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particular Tet2 null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.

    • Feng Pan
    • , Thomas S. Wingo
    • , Zhigang Zhao
    • , Rui Gao
    • , Hideki Makishima
    • , Guangbo Qu
    • , Li Lin
    • , Miao Yu
    • , Janice R. Ortega
    • , Jiapeng Wang
    • , Aziz Nazha
    • , Li Chen
    • , Bing Yao
    • , Can Liu
    • , Shi Chen
    • , Ophelia Weeks
    • , Hongyu Ni
    • , Brittany Lynn Phillips
    • , Suming Huang
    • , Jianlong Wang
    • , Chuan He
    • , Guo-Min Li
    • , Tomas Radivoyevitch
    • , Iannis Aifantis
    • , Jaroslaw P. Maciejewski
    • , Feng-Chun Yang
    • , Peng Jin
    •  & Mingjiang Xu
  • Corrigendum | | open

    • Kuan-lin Huang
    • , Shunqiang Li
    • , Philipp Mertins
    • , Song Cao
    • , Harsha P. Gunawardena
    • , Kelly V. Ruggles
    • , D. R. Mani
    • , Karl R. Clauser
    • , Maki Tanioka
    • , Jerry Usary
    • , Shyam M. Kavuri
    • , Ling Xie
    • , Christopher Yoon
    • , Jana W. Qiao
    • , John Wrobel
    • , Matthew A. Wyczalkowski
    • , Petra Erdmann-Gilmore
    • , Jacqueline E. Snider
    • , Jeremy Hoog
    • , Purba Singh
    • , Beifang Niu
    • , Zhanfang Guo
    • , Sam Qiancheng Sun
    • , Souzan Sanati
    • , Emily Kawaler
    • , Xuya Wang
    • , Adam Scott
    • , Kai Ye
    • , Michael D. McLellan
    • , Michael C. Wendl
    • , Anna Malovannaya
    • , Jason M. Held
    • , Michael A. Gillette
    • , David Fenyö
    • , Christopher R. Kinsinger
    • , Mehdi Mesri
    • , Henry Rodriguez
    • , Sherri R. Davies
    • , Charles M. Perou
    • , Cynthia Ma
    • , R. Reid Townsend
    • , Xian Chen
    • , Steven A. Carr
    • , Matthew J. Ellis
    •  & Li Ding
  • Article | | open

    The ability to support the development of a premature fetus in the form of an extracorporeal system has had limited success. Here, the authors show that an extra-uterine device that mimics the intra-uterine environment can provide physiologic support for the extreme premature lamb fetus for four weeks.

    • Emily A. Partridge
    • , Marcus G. Davey
    • , Matthew A. Hornick
    • , Patrick E. McGovern
    • , Ali Y. Mejaddam
    • , Jesse D. Vrecenak
    • , Carmen Mesas-Burgos
    • , Aliza Olive
    • , Robert C. Caskey
    • , Theodore R. Weiland
    • , Jiancheng Han
    • , Alexander J. Schupper
    • , James T. Connelly
    • , Kevin C. Dysart
    • , Jack Rychik
    • , Holly L. Hedrick
    • , William H. Peranteau
    •  & Alan W. Flake
  • Article | | open

    In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.

    • Amy T. Y. Yeung
    • , Christine Hale
    • , Amy H. Lee
    • , Erin E. Gill
    • , Wendy Bushell
    • , David Parry-Smith
    • , David Goulding
    • , Derek Pickard
    • , Theodoros Roumeliotis
    • , Jyoti Choudhary
    • , Nick Thomson
    • , William C. Skarnes
    • , Gordon Dougan
    •  & Robert E. W. Hancock
  • Article | | open

    Controlling surface wettability using visible light is highly attractive for a range of liquid separation technologies. Here, Varanasi, McKinley and colleagues fabricate dye-sensitized photocatalytic TiO2 surfaces on which liquid droplet motion can be externally manipulated by visible light illumination.

    • Gibum Kwon
    • , Divya Panchanathan
    • , Seyed Reza Mahmoudi
    • , Mohammed A. Gondal
    • , Gareth H. McKinley
    •  & Kripa K. Varanasi