Browse Articles

  • Article | | open

    Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles characterized by chromothripsis-amplification.

    • Sam Behjati
    • , Patrick S. Tarpey
    • , Kerstin Haase
    • , Hongtao Ye
    • , Matthew D. Young
    • , Ludmil B. Alexandrov
    • , Sarah J. Farndon
    • , Grace Collord
    • , David C. Wedge
    • , Inigo Martincorena
    • , Susanna L. Cooke
    • , Helen Davies
    • , William Mifsud
    • , Mathias Lidgren
    • , Sancha Martin
    • , Calli Latimer
    • , Mark Maddison
    • , Adam P. Butler
    • , Jon W. Teague
    • , Nischalan Pillay
    • , Adam Shlien
    • , Ultan McDermott
    • , P. Andrew Futreal
    • , Daniel Baumhoer
    • , Olga Zaikova
    • , Bodil Bjerkehagen
    • , Ola Myklebost
    • , M. Fernanda Amary
    • , Roberto Tirabosco
    • , Peter Van Loo
    • , Michael R. Stratton
    • , Adrienne M. Flanagan
    •  & Peter J. Campbell
  • Article | | open

    Robust implementations of semiconducting qubits require overcoming the effects of charge noise, which limits coherence times. Here the authors propose a decoherence-free subspace for charge qubits to protect them from uniform electric field fluctuations, proposing an implementation in a triple quantum dot.

    • Mark Friesen
    • , Joydip Ghosh
    • , M. A. Eriksson
    •  & S. N. Coppersmith
  • Article | | open

    Holes in endothelial barriers, called transendothelial cell macroapertures (TEMs), are predicted to be limited by line tension of unknown origin. Here the authors identify an actomyosin cable encircling TEMs and establish a role for ezrin in stabilising F-actin bundles, allowing their crosslinking by non-muscle myosin IIa.

    • Caroline Stefani
    • , David Gonzalez-Rodriguez
    • , Yosuke Senju
    • , Anne Doye
    • , Nadia Efimova
    • , Sébastien Janel
    • , Justine Lipuma
    • , Meng Chen Tsai
    • , Daniel Hamaoui
    • , Madhavi P. Maddugoda
    • , Olivier Cochet-Escartin
    • , Coline Prévost
    • , Frank Lafont
    • , Tatyana Svitkina
    • , Pekka Lappalainen
    • , Patricia Bassereau
    •  & Emmanuel Lemichez
  • Article | | open

    Stroke recovery requires circuit reorganization and therapeutic efforts have focused on rewiring cortical circuits after stroke, but what about thalamic inputs? Here, the authors examine how thalamocortical axons are affected by stroke and use optogenetic stimulation to promote recovery.

    • Kelly A. Tennant
    • , Stephanie L. Taylor
    • , Emily R. White
    •  & Craig E. Brown
  • Article | | open

    Electric field control of magnetization is usually weak and this hampers its application for the ultralow-power-consumption spintronic devices. Here, the authors demonstrate a mechanism to enhance the control of magnetic anisotropy by voltage-induced electric quadrupole in a metal–dielectric interface.

    • Shinji Miwa
    • , Motohiro Suzuki
    • , Masahito Tsujikawa
    • , Kensho Matsuda
    • , Takayuki Nozaki
    • , Kazuhito Tanaka
    • , Takuya Tsukahara
    • , Kohei Nawaoka
    • , Minori Goto
    • , Yoshinori Kotani
    • , Tadakatsu Ohkubo
    • , Frédéric Bonell
    • , Eiiti Tamura
    • , Kazuhiro Hono
    • , Tetsuya Nakamura
    • , Masafumi Shirai
    • , Shinji Yuasa
    •  & Yoshishige Suzuki
  • Article | | open

    Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infection in vitro, but their role in vivo remains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika viremia.

    • Petraleigh Pantoja
    • , Erick X. Pérez-Guzmán
    • , Idia V. Rodríguez
    • , Laura J. White
    • , Olga González
    • , Crisanta Serrano
    • , Luis Giavedoni
    • , Vida Hodara
    • , Lorna Cruz
    • , Teresa Arana
    • , Melween I. Martínez
    • , Mariah A. Hassert
    • , James D. Brien
    • , Amelia K. Pinto
    • , Aravinda de Silva
    •  & Carlos A. Sariol
  • Article | | open

    Cryptochrome 2 (CRY2) from A. thaliana can be used to control light-dependent protein homo-oligomerization, but the molecular mechanism of CRY2 clustering is not known, limiting its application. Here the authors identify determinants of CRY2 clustering and engineer fusion partners to modulate clustering efficiency.

    • Hyerim Park
    • , Na Yeon Kim
    • , Sangkyu Lee
    • , Nury Kim
    • , Jihoon Kim
    •  & Won Do Heo
  • Article | | open

    The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading onto DNA.

    • Jordi Frigola
    • , Jun He
    • , Kerstin Kinkelin
    • , Valerie E. Pye
    • , Ludovic Renault
    • , Max E. Douglas
    • , Dirk Remus
    • , Peter Cherepanov
    • , Alessandro Costa
    •  & John F. X. Diffley
  • Article | | open

    Viruses play an important role in microbial communities but, due to limitations of available techniques, our understanding of viral diversity is limited. Here, the authors use SVGs and identify highly abundant viruses in marine communities that have been previously overlooked.

    • Francisco Martinez-Hernandez
    • , Oscar Fornas
    • , Monica Lluesma Gomez
    • , Benjamin Bolduc
    • , Maria Jose de la Cruz Peña
    • , Joaquín Martínez Martínez
    • , Josefa Anton
    • , Josep M. Gasol
    • , Riccardo Rosselli
    • , Francisco Rodriguez-Valera
    • , Matthew B. Sullivan
    • , Silvia G. Acinas
    •  & Manuel Martinez-Garcia
  • Article | | open

    Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.

    • Yali Xue
    • , Massimo Mezzavilla
    • , Marc Haber
    • , Shane McCarthy
    • , Yuan Chen
    • , Vagheesh Narasimhan
    • , Arthur Gilly
    • , Qasim Ayub
    • , Vincenza Colonna
    • , Lorraine Southam
    • , Christopher Finan
    • , Andrea Massaia
    • , Himanshu Chheda
    • , Priit Palta
    • , Graham Ritchie
    • , Jennifer Asimit
    • , George Dedoussis
    • , Paolo Gasparini
    • , Aarno Palotie
    • , Samuli Ripatti
    • , Nicole Soranzo
    • , Daniela Toniolo
    • , James F. Wilson
    • , Richard Durbin
    • , Chris Tyler-Smith
    •  & Eleftheria Zeggini
  • Article | | open

    Several living organisms can survive subzero temperatures without cell damage. Here, the authors show a heteronetwork organohydrogel with improved elasticity and mechanical features in a wide range of temperatures.

    • Hainan Gao
    • , Ziguang Zhao
    • , Yudong Cai
    • , Jiajia Zhou
    • , Wenda Hua
    • , Lie Chen
    • , Li Wang
    • , Jianqi Zhang
    • , Dong Han
    • , Mingjie Liu
    •  & Lei Jiang
  • Article | | open

    It is an open challenge to implement a coherent quantum annealer with fully programmable all-to-all connectivity. Here the authors present a scheme based on enhanced Rydberg-dressed interactions between neutral atoms in an optical lattice which is programmable by individual addressing of local fields.

    • A. W. Glaetzle
    • , R. M. W. van Bijnen
    • , P. Zoller
    •  & W. Lechner
  • Article | | open

    Quasicrystals possess long-range order but lack translational symmetry. Here, the authors use atomic manipulation and scanning tunnelling microscopy to assemble a Penrose tiling quasicrystal and observe that its electronic density of states has a quasiperiodic order, linked to the quasicrystal topology.

    • Laura C. Collins
    • , Thomas G. Witte
    • , Rochelle Silverman
    • , David B. Green
    •  & Kenjiro K. Gomes
  • Article | | open

    Many photo-induced processes such as photosynthesis occur in organic molecules, but their femtosecond excited-state dynamics are difficult to track. Here, the authors exploit the element and site selectivity of soft X-ray absorption to sensitively follow the ultrafast ππ*/* electronic relaxation of hetero-organic molecules.

    • T. J. A. Wolf
    • , R. H. Myhre
    • , J. P. Cryan
    • , S. Coriani
    • , R. J. Squibb
    • , A. Battistoni
    • , N. Berrah
    • , C. Bostedt
    • , P. Bucksbaum
    • , G. Coslovich
    • , R. Feifel
    • , K. J. Gaffney
    • , J. Grilj
    • , T. J. Martinez
    • , S. Miyabe
    • , S. P. Moeller
    • , M. Mucke
    • , A. Natan
    • , R. Obaid
    • , T. Osipov
    • , O. Plekan
    • , S. Wang
    • , H. Koch
    •  & M. Gühr
  • Article | | open

    Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.

    • Mariola Kurowska-Stolarska
    • , Stefano Alivernini
    • , Emma Garcia Melchor
    • , Aziza Elmesmari
    • , Barbara Tolusso
    • , Clare Tange
    • , Luca Petricca
    • , Derek S. Gilchrist
    • , Gabriele Di Sante
    • , Chantal Keijzer
    • , Lynn Stewart
    • , Clara Di Mario
    • , Vicky Morrison
    • , James M. Brewer
    • , Duncan Porter
    • , Simon Milling
    • , Ronald D. Baxter
    • , David McCarey
    • , Elisa Gremese
    • , Greg Lemke
    • , Gianfranco Ferraccioli
    • , Charles McSharry
    •  & Iain B. McInnes
  • Article | | open

    The signature of short range resonating valence bonds (RVB) to understand quantum spin liquids is yet to be explored. Here, Li et al. observe the putative RVB correlations restricted to nearest neighbours in YbMgGaO4, responsible for the high-energy spin excitations.

    • Yuesheng Li
    • , Devashibhai Adroja
    • , David Voneshen
    • , Robert I. Bewley
    • , Qingming Zhang
    • , Alexander A. Tsirlin
    •  & Philipp Gegenwart
  • Article | | open

    Atomically thin boron nitride remains undercharacterized in terms of their mechanical properties. Here authors test high-quality mono- and few-layer BN and show it to be one of the strongest electrically insulating materials and dramatically better in interlayer integrity than graphene under indentation.

    • Aleksey Falin
    • , Qiran Cai
    • , Elton J.G. Santos
    • , Declan Scullion
    • , Dong Qian
    • , Rui Zhang
    • , Zhi Yang
    • , Shaoming Huang
    • , Kenji Watanabe
    • , Takashi Taniguchi
    • , Matthew R. Barnett
    • , Ying Chen
    • , Rodney S. Ruoff
    •  & Lu Hua Li
  • Article | | open

    The rate of subsea permafrost degradation is a key factor controlling marine methane emissions in the Arctic. Here, using re-drilled boreholes, the authors show that the ice-bonded permafrost table in the near-shore East Siberian Arctic Shelf has deepened by 14 cm per year over the past 31–32 years.

    • Natalia Shakhova
    • , Igor Semiletov
    • , Orjan Gustafsson
    • , Valentin Sergienko
    • , Leopold Lobkovsky
    • , Oleg Dudarev
    • , Vladimir Tumskoy
    • , Michael Grigoriev
    • , Alexey Mazurov
    • , Anatoly Salyuk
    • , Roman Ananiev
    • , Andrey Koshurnikov
    • , Denis Kosmach
    • , Alexander Charkin
    • , Nicolay Dmitrevsky
    • , Victor Karnaukh
    • , Alexey Gunar
    • , Alexander Meluzov
    •  & Denis Chernykh
  • Article | | open

    Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.

    • Yosuke M. Morizawa
    • , Yuri Hirayama
    • , Noubuhiko Ohno
    • , Shinsuke Shibata
    • , Eiji Shigetomi
    • , Yang Sui
    • , Junichi Nabekura
    • , Koichi Sato
    • , Fumikazu Okajima
    • , Hirohide Takebayashi
    • , Hideyuki Okano
    •  & Schuichi Koizumi
  • Article | | open

    Two-dimensional MoS2 homojunctions, considered potential building blocks for next generation flexible electronics, currently suffer from quick degradation. Here, Zhang and co-workers use a self-healing sulfur vacancy mechanism to produce a MoS2 photodiode that possesses long term stability.

    • Xiankun Zhang
    • , Qingliang Liao
    • , Shuo Liu
    • , Zhuo Kang
    • , Zheng Zhang
    • , Junli Du
    • , Feng Li
    • , Shuhao Zhang
    • , Jiankun Xiao
    • , Baishan Liu
    • , Yang Ou
    • , Xiaozhi Liu
    • , Lin Gu
    •  & Yue Zhang
  • Article | | open

    Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites.

    • Axel von Kamp
    •  & Steffen Klamt
  • Article | | open

    D-band engineering via alloying platinum is a leading design principle for advanced oxygen reduction electrocatalysts, but stability remains a concern. Here the authors make Pt nanoparticles supported on graphite-rich boron carbide for enhanced activity and stability, isolating and optimizing the electronic metal-support interactions.

    • Colleen Jackson
    • , Graham T. Smith
    • , David W. Inwood
    • , Andrew S. Leach
    • , Penny S. Whalley
    • , Mauro Callisti
    • , Tomas Polcar
    • , Andrea E. Russell
    • , Pieter Levecque
    •  & Denis Kramer
  • Article | | open

    HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmission in vitro, and increases the number of infected clones in mice.

    • Florent Percher
    • , Céline Curis
    • , Eléonore Pérès
    • , Maria Artesi
    • , Nicolas Rosewick
    • , Patricia Jeannin
    • , Antoine Gessain
    • , Olivier Gout
    • , Renaud Mahieux
    • , Pierre-Emmanuel Ceccaldi
    • , Anne Van den Broeke
    • , Madeleine Duc Dodon
    •  & Philippe V. Afonso