Browse Articles

  • Article | | open

    Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

    • Yiguo Shen
    • , David Kapfhamer
    • , Angela M. Minnella
    • , Ji-Eun Kim
    • , Seok Joon Won
    • , Yanting Chen
    • , Yong Huang
    • , Ley Hian Low
    • , Stephen M. Massa
    •  & Raymond A. Swanson
  • Article | | open

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article | | open

    Spintronic devices with full electrical control rely on electrical generation and detection of spin currents in the absence of magnetic materials. Here, the authors use Pt, a non-magnetic metal, to generate and detect pure spin currents in a few-layer graphene channel, achieving a remarkable spin-to-charge voltage signal at room temperature.

    • Wenjing Yan
    • , Edurne Sagasta
    • , Mário Ribeiro
    • , Yasuhiro Niimi
    • , Luis E. Hueso
    •  & Fèlix Casanova
  • Article | | open

    O-linked β-N-acetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA). Here the authors give insights into OGA substrate recognition by presenting four human OGA structures complexed with glycopeptide substrates containing a single O-GlcNAc modification on either a serine or threonine.

    • Baobin Li
    • , Hao Li
    • , Chia-Wei Hu
    •  & Jiaoyang Jiang
  • Article | | open

    The development of future computation devices will be aided by a better understanding of the physics underlying material behaviors. Using thermoreflectance and spatially resolved X-ray microscopy, Kumar et al. elucidate the origin of two types of negative differential resistance in NbO2 memristors.

    • Suhas Kumar
    • , Ziwen Wang
    • , Noraica Davila
    • , Niru Kumari
    • , Kate J. Norris
    • , Xiaopeng Huang
    • , John Paul Strachan
    • , David Vine
    • , A.L. David Kilcoyne
    • , Yoshio Nishi
    •  & R. Stanley Williams
  • Article | | open

    Avenaol is a potent germination stimulant that can be extracted from black oat. Here, the authors report the total synthesis of avenaol by developing a strategy to access all-cis-substituted cyclopropanes.

    • Motohiro Yasui
    • , Rina Ota
    • , Chihiro Tsukano
    •  & Yoshiji Takemoto
  • Article | | open

    One of the challenges in studies of quantum many-body physics is finding an efficient way to record the large system wavefunctions. Here the authors present an analysis of the capabilities of recently-proposed neural network representations for storing physically accessible quantum states.

    • Xun Gao
    •  & Lu-Ming Duan
  • Article | | open

    Cells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes in distinct domains for one-pot, tandem reactions.

    • Hongliang Tan
    • , Song Guo
    • , Ngoc-Duy Dinh
    • , Rongcong Luo
    • , Lin Jin
    •  & Chia-Hung Chen
  • Article | | open

    Two-dimensional topological insulators support edge conduction electrons but its realization in real materials is rare. Here, Peng et al. report the direct observation of topological states at the step edge of WTe2.

    • Lang Peng
    • , Yuan Yuan
    • , Gang Li
    • , Xing Yang
    • , Jing-Jing Xian
    • , Chang-Jiang Yi
    • , You-Guo Shi
    •  & Ying-Shuang Fu
  • Article | | open

    Classifying groups is an important challenge in mathematics and has led to the identification of groups which do not belong to the main families. Here Duncan et al. introduce a type of moonshine which is a connection between these groups, number theory and potentially physics.

    • John F. R. Duncan
    • , Michael H. Mertens
    •  & Ken Ono
  • Article | | open

    Proteins fold under mechanical force during co-translational folding at the ribosome. Here, the authors use single molecule magnetic tweezers to study the influence of chaperones on protein folding and show that the ribosomal chaperone trigger factor acts as a mechanical foldase by promoting protein folding under force.

    • Shubhasis Haldar
    • , Rafael Tapia-Rojo
    • , Edward C. Eckels
    • , Jessica Valle-Orero
    •  & Julio M. Fernandez
  • Article | | open

    Slow oscillations between cortical Up and Down states are a defining feature of deep sleep, but their function is not well understood. Here the authors study Up/Down states in acute slices of entorhinal cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserved or strengthened.

    • Julian Bartram
    • , Martin C. Kahn
    • , Simon Tuohy
    • , Ole Paulsen
    • , Tony Wilson
    •  & Edward O. Mann
  • Article | | open

    Polycomb repressive complex 2 (PRC2) plays an essential role in development by modifying chromatin but what this means at a cellular level is unclear. Here, the authors show that ablation of PRC2 genes in human embryonic stem cells and in mice results in changes in pluripotency and the primed state of cells.

    • Yongli Shan
    • , Zechuan Liang
    • , Qi Xing
    • , Tian Zhang
    • , Bo Wang
    • , Shulan Tian
    • , Wenhao Huang
    • , Yanqi Zhang
    • , Jiao Yao
    • , Yanling Zhu
    • , Ke Huang
    • , Yujian Liu
    • , Xiaoshan Wang
    • , Qianyu Chen
    • , Jian Zhang
    • , Bizhi Shang
    • , Shengbiao Li
    • , Xi Shi
    • , Baojian Liao
    • , Cong Zhang
    • , Keyu Lai
    • , Xiaofen Zhong
    • , Xiaodong Shu
    • , Jinyong Wang
    • , Hongjie Yao
    • , Jiekai Chen
    • , Duanqing Pei
    •  & Guangjin Pan
  • Article | | open

    CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often repaired by mutagenic non-homologous end-joining. Here the authors use Cas9 nickases to generate coordinated single-strand breaks in donor and target DNA for precise homology-directed gene editing.

    • Xiaoyu Chen
    • , Josephine M. Janssen
    • , Jin Liu
    • , Ignazio Maggio
    • , Anke E. J. ‘t Jong
    • , Harald M.M. Mikkers
    •  & Manuel A. F. V. Gonçalves
  • Article | | open

    Engineering a coupling between magnetic molecules and conducting materials at room temperature could help the development of spintronic devices. Loh et al. show that the spin state of QDTP molecules deposited on graphene and MoS2 couples to their electronic structure, affecting magnetotransport.

    • Subhadeep Datta
    • , Yongqing Cai
    • , Indra Yudhistira
    • , Zebing Zeng
    • , Yong-Wei Zhang
    • , Han Zhang
    • , Shaffique Adam
    • , Jishan Wu
    •  & Kian Ping Loh
  • Article | | open

    A skyrmion is a topological object originally introduced to model elementary particles and a baby skyrmion is its two-dimensional counterpart which can be realized as a defect in liquid crystals. Here the authors show that an electric field can drive uniform motion of baby skyrmions in liquid crystals.

    • Paul J. Ackerman
    • , Timothy Boyle
    •  & Ivan I. Smalyukh
  • Article | | open

    Metal oxide nanocrystals can be grown with different facets exposed to give variations in reactivity, but the chemical state of these surfaces is not clear. Here, the authors make use of a phosphine probe molecule allowing the differences in surface chemistry to be mapped by NMR spectroscopy.

    • Yung-Kang Peng
    • , Yichen Hu
    • , Hung-Lung Chou
    • , Yingyi Fu
    • , Ivo F. Teixeira
    • , Li Zhang
    • , Heyong He
    •  & Shik Chi Edman Tsang
  • Article | | open

    Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.

    • Hongqing Du
    • , Chung-Hsuan Shih
    • , Michael N. Wosczyna
    • , Alisa A. Mueller
    • , Joonseok Cho
    • , Abhishek Aggarwal
    • , Thomas A. Rando
    •  & Brian J. Feldman
  • Article | | open

    Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.

    • Sumeet Pal Singh
    • , Sharan Janjuha
    • , Theresa Hartmann
    • , Özge Kayisoglu
    • , Judith Konantz
    • , Sarah Birke
    • , Priyanka Murawala
    • , Ezzaldin Ahmed Alfar
    • , Kei Murata
    • , Anne Eugster
    • , Naoki Tsuji
    • , Edward R. Morrissey
    • , Michael Brand
    •  & Nikolay Ninov
  • Article | | open

    Colloidal self-assembly is a unique method to produce three-dimensional materials with well-defined hierarchical structures and functionalities. Liljeström et al. show controlled preparation of macroscopic chiral wires with helical plasmonic superlattice structure composed of metal nanoparticles and viruses.

    • Ville Liljeström
    • , Ari Ora
    • , Jukka Hassinen
    • , Heikki T. Rekola
    • , Nonappa
    • , Maria Heilala
    • , Ville Hynninen
    • , Jussi J. Joensuu
    • , Robin H. A. Ras
    • , Päivi Törmä
    • , Olli Ikkala
    •  & Mauri A. Kostiainen
  • Article | | open

    Assembly of filamentous RSV particles is incompletely understood due to a lack of techniques suitable for live-cell imaging. Here Vanover et al. use labeled soybean agglutinin to selectively label RSV G protein and show how filamentous RSV assembly, initiated in the cytoplasm, uses G protein recycled from the plasma membrane.

    • Daryll Vanover
    • , Daisy V. Smith
    • , Emmeline L. Blanchard
    • , Eric Alonas
    • , Jonathan L. Kirschman
    • , Aaron W. Lifland
    • , Chiara Zurla
    •  & Philip J. Santangelo
  • Article | | open

    Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.

    • Chao Shan
    • , Antonio E. Muruato
    • , Brett W. Jagger
    • , Justin Richner
    • , Bruno T. D. Nunes
    • , Daniele B. A. Medeiros
    • , Xuping Xie
    • , Jannyce G. C. Nunes
    • , Kaitlyn M. Morabito
    • , Wing-Pui Kong
    • , Theodore C. Pierson
    • , Alan D. Barrett
    • , Scott C. Weaver
    • , Shannan L. Rossi
    • , Pedro F. C. Vasconcelos
    • , Barney S. Graham
    • , Michael S. Diamond
    •  & Pei-Yong Shi
  • Article | | open

    The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.

    • Shreya Mitra
    • , Jeffrey E. Montgomery
    • , Matthew J. Kolar
    • , Gang Li
    • , Kang J. Jeong
    • , Bo Peng
    • , Gregory L. Verdine
    • , Gordon B. Mills
    •  & Raymond E. Moellering
  • Article | | open

    The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific binding affinities.

    • Nana Diarra dit Konté
    • , Miroslav Krepl
    • , Fred F. Damberger
    • , Nina Ripin
    • , Olivier Duss
    • , Jiří Šponer
    •  & Frédéric H.-T. Allain
  • Article | | open

    Nature can precisely control monomer sequences in biopolymers, but this is somewhat problematic in the formation of synthetic polymers. Here the authors show sequence-controlled supramolecular terpolymerization via self-sorting behavior among three sets of monomers possessing mismatched host-guest pairs.

    • Takehiro Hirao
    • , Hiroaki Kudo
    • , Tomoko Amimoto
    •  & Takeharu Haino