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Trainable responsive materials have received research interests for future adaptive and intelligent material systems but to date trainable responsive materials only allow one direction of functionality change. Here, the authors demonstrate thermally trainable hydrogel systems consisting of two thermoresponsive polymers, where the volumetric response of the system upon phase transitions enhances or decreases through a training process above a certain threshold temperature.
The choroid plexus (ChP) modulates cerebrospinal fluid (CSF) composition and the blood-CSF barrier. Here the authors show that the ChP is a critical circadian component with time-of-day variations in translation, barrier, and metabolism to alter CSF composition.
The Wnt enhanceosome is responsible for the transactivation of Wnt target genes in response to stimulation of cells by extracellular Wnt signals. Here, Wang et al. show BCL9, Pygo, LDB1 and SSBP form a stable core complex within the Wnt enhanceosome. Furthermore, they determine the crystal structure of the Pygo2-LDB1-SSBP2 ternary complex, which provides a promising therapeutic target for blocking Wnt/β-catenin signaling in cancer.
Studies of early brain development often rely on cross sectional data. Here the authors investigate volumetric development and surface area expansion of six subcortical structures using longitudinal MRI scans within the first two postnatal years.
Accuracy loss and slow speed affect the identification of compounds through matching of mass spectra using a large-scale spectral library. Here the authors use Word2vec spectral embedding and hierarchical navigable small-world graph to improve accuracy and speed of spectral matching on their own million-scale in-silico library.
Turbulence is an important ventilator of near-surface pollution but is also influenced by it. Here we find that turbulence is likely to increase with mitigating black carbon emissions, providing an added positive impact in highly polluted regions.
Dilated cardiomyopathy is the second most common cause for heart failure. Here the authors combine CRISPR base editors with the muscle-targeting viral vector AAVMYO to repair patient mutations in the cardiac splice factor Rbm20 in two mouse models.
Mutations that impact the function of the Arp2/3 complex are known to cause inborn errors of immunity. Here the authors describe biallelic null mutations in the ARPC5 subunit of Arp2/3 that disrupt actin function and cytokine signaling, causing infections, autoimmunity, inflammation and dysmorphisms.
Over 25,000 synthesized experiments identify effective land management practices, such as tree planting and biochar use, that partially mitigate land-use change effects. Yet, indirect climate change effects still pose a potential severe threat to SOC globally
Microplastics the marine atmosphere are a highly relevant subject, yet barely investigated. This study showed their ubiquity in the nanogram range even in remote Artic regions and depict the ocean acts as both a sink and source for microplastics
Thermoelectric property of silicon itself is important for the thermal management of post-Moore nanoelectronics. Here, Xue et al directly observe unconventional thermoelectric cooling/heating effects enhanced by hot electrons in silicon nanodevices.
Constructing 2D/3D perovskite heterojunctions is effective for the surface passivation of perovskite solar cells. Here, the authors apply Cl2-dissolved chloroform as a multifunctional solvent and achieve a champion device efficiency of 24.21% with improved thermal, ambient and operational stability.
Recognition on sources of polyhalogenated carbazoles is needed to understand their environmental accumulation. Here, release of polyhalogenated carbazoles from 13 industries including 122 plants is identified and estimated.
Only praziquantel is available for treating schistosomiasis, a disease affecting >200 million people. Here, the authors identify compounds active against schistosome infections meeting the criteria for lead progression indicated by WHO with better activity against juvenile worms than praziquantel.
One of the main hurdles to curing HIV infection are viral reservoirs. Here, the authors develop a trispecific antibody and demonstrate its ability to simultaneously activate and target latently HIV−1 infected cells for elimination by T cells as an alternative strategy for HIV cure.
Generation of mature oocytes requires tight regulation of a discontinuous meiotic cell cycle. Here they show that the acetyltransferase Nat10 mediates modification of RNAs targeted for degradation and find that this process is essential for female oocyte meiosis and maturation.
In inflammatory arthritis, pain neurons communicate with spinal cord microglia to establish nociception. Here, the authors show that this communication is mediated by pain neurons releasing galectin-3, which activates microglia through TLR4. In a mouse model of Alzheimer’s disease, pain is attenuated because microglia lack expression of TLR4.
Gastric cancers (GC) are driven by genomic alterations, but the underlying molecular mechanisms remain unclear. Here, the authors analyse the structural rearrangement landscape of 170 GCs using whole-genome sequencing, identify recurrent structural variant hotspots and find oncogene amplicons driven by extrachromosomal DNA.
The mechanisms regulating granule secretion are not fully understood. Here the authors show that tetraspanin-8 sequesters syntaxin-2 at the cell surface, limiting the syntaxin available for fusion and the quantities of mucin secreted. This mechanism may also apply to insulin release
Sphingolipids can function as lipid signaling molecules. Here, the authors find that the endoplasmic reticulum calcium channel Csg2 integrates sphingolipid metabolism with autophagy by regulating calcium homeostasis in endoplasmic reticulum.