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Volume 17 Issue 4, April 2021

Volume 17 Issue 4

Keeping translation on track

The cover illustrates the synthetic protein quality control (ProQC) system, in which a 5’ toehold switch hybridizes with a trigger sequence at the 3’ end of the mRNA to facilitate ribosomal translation of full-length proteins.

See Yang et al.

Image: Younghee Lee, CUBE3D Graphic. Cover Design: Alex Wing.

Comment

  • Comment | | Open Access

    Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

    • Michelle A. Schorn
    • Stefan Verhoeven
    • Justin J. J. van der Hooft

Research Highlights

News & Views

  • News & Views |

    High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.

    • Kanishk Jain
    • Brian D. Strahl
  • News & Views |

    Acyl protein thioesterases are critical regulators of S-acylation, removing acyl chains from dynamically S-acylated proteins. A cytosolic deacylase, APT2, is S-acylated by zDHHC3 and zDHHC7 and is predicted to deform the lipid bilayer to extract acyl chains, capturing them within a hydrophobic pocket.

    • Jennifer Greaves
  • News & Views |

    A genetically encoded real-time redox reporter reveals that H2O2-signaling peroxiredoxin (PRX) proteins couple yeast metabolic oscillations with the cell division cycle. This new PRX function suggests fresh avenues for exploring circadian regulation of cell division and cancer.

    • John S. O’Neill

Perspectives

  • Perspective |

    This Perspective summarizes the known types of ligand-controlled ribozymes and riboswitches and discusses the reasons why allosteric ribozymes formed by fusion of RNA enzymes and RNA aptamers are rare in today’s biological systems.

    • Shanker S. S. Panchapakesan
    • Ronald R. Breaker

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