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REDOX BIOLOGY

Redox-coupled rhythm and brews

A genetically encoded real-time redox reporter reveals that H2O2-signaling peroxiredoxin (PRX) proteins couple yeast metabolic oscillations with the cell division cycle. This new PRX function suggests fresh avenues for exploring circadian regulation of cell division and cancer.

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Fig. 1: Respiratory oscillations impose metabolic checkpoints on cell cycle progression in S. cerevisiae.

References

  1. Amponsah, P. S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-00728-9 (2021).

    Article  PubMed  Google Scholar 

  2. Burnetti, A. J., Aydin, M. & Buchler, N. E. Mol. Biol. Cell 27, 64–74 (2016).

    Article  CAS  Google Scholar 

  3. Chen, Z., Odstrcil, E. A., Tu, B. P. & McKnight, S. L. Science 316, 1916–1919 (2007).

    Article  CAS  Google Scholar 

  4. Feltham, J. E. et al. Preprint at bioRxiv https://doi.org/10.1101/833921 (2020).

  5. O’ Neill, J. S. et al. Nat. Commun. 11, 4706 (2020).

    Article  Google Scholar 

  6. Causton, H. C., Feeney, K. A., Ziegler, C. A. & O’Neill, J. S. Curr. Biol. 25, 1056–1062 (2015).

    Article  CAS  Google Scholar 

  7. Stöcker, S., Van Laer, K., Mijuskovic, A. & Dick, T. P. Antioxid. Redox Signal. 28, 558–573 (2018).

    Article  Google Scholar 

  8. Putker, M. et al. Antioxid. Redox Signal. 28, 507–520 (2018).

    Article  CAS  Google Scholar 

  9. O’Neill, J. S. et al. Curr. Biol. 25, R326–R327 (2015).

    Article  Google Scholar 

  10. Edgar, R. S. et al. Nature 485, 459–464 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to John S. O’Neill.

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O’Neill, J.S. Redox-coupled rhythm and brews. Nat Chem Biol 17, 373–374 (2021). https://doi.org/10.1038/s41589-021-00777-8

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