Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 16 Issue 3, March 2020

Targeting bacterial bile salts

The bacteria of the human microbiota use bile salt hydrolases (BSHs) to generate dozens of secondary bile acids that can bind to host receptors, including nuclear receptors and G-protein-coupled receptors. A covalent inhibitor generated by appending an electrophile to the sterol core of a bile acid can inhibit all of the BSH activity in rodent microbiota and could prove useful for understanding the effects of bile acids on host physiology.

See Adhikari et al

IMAGE: Leah Bury COVER DESIGN: Erin Dewalt

Research Highlights

Top of page ⤴

News & Views

  • Characterization of biased receptor signaling has ushered in opportunities for unprecedented control of G-protein-coupled receptors. Elucidation of distinct M1 muscarinic acetylcholine receptor signaling pathways and development of biased ligands may offer novel and safer Alzheimer’s disease therapeutics.

    • Sean P. Moran
    • P. Jeffrey Conn
    News & Views
  • The site-specific monoubiquitination of FANCD2 is crucial for the Fanconi anemia DNA repair pathway and tumor suppression. This modification is mediated by the E2 enzyme UBE2T and the E3 ligase FANCL through a novel allosteric mechanism.

    • Koichi Sato
    • Puck Knipscheer
    News & Views
  • Retro-2 is a drug that protects cells against bacterial and plant toxins by arresting their trafficking in endosomes. New data show that the target for Retro-2 is surprisingly not within the endosomal system, but on the endoplasmic reticulum.

    • Hesso Farhan
    News & Views
Top of page ⤴

Review Articles

Top of page ⤴


Top of page ⤴

Amendments & Corrections

Top of page ⤴


Quick links