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Volume 14 Issue 11, November 2018

Volume 14 Issue 11

Preventing codon slippage

The cover depicts the structure of tRNAMet bearing an N 4-acetylcytidine (ac4C) modification at the first position of the anticodon. The acetyltransferase TmcAL introduces the ac4C modification, and loss of TmcAL results in misdecoding of the AUA codon.

See Taniguchi et al.

Image: Be Design Inc. Cover design: Erin Dewalt

Research Highlights

News & Views

  • News & Views |

    The prodrug dimethyloxalylglycine (DMOG) is a well-known tool compound used to study hypoxia. New findings reveal that DMOG also inhibits glutamine metabolism and can be exploited to selectively kill some cancer cells, highlighting important caveats when using DMOG for hypoxia studies.

    • Barbara S. Nelson
    • Daniel M. Kremer
    • Costas A. Lyssiotis
  • News & Views |

    The proteome-wide application of a probe that selectively labels cysteine residues oxidized to the sulfinic acid form reveals the mammalian S-sulfinylome and uncovers novel substrates of the sulfinyl reductase sulfiredoxin, opening yet unexplored realms of cysteine-based redox regulation.

    • Sophie Rahuel-Clermont
    • Michel B. Toledano
  • News & Views |

    A Donnan equilibrium causes an influx of chloride ions into the Escherichia coli periplasm when the bacterium finds itself in gastric fluid. The combination of low pH and high anion concentration drives proteins to aggregate, a potentially lethal event unless prevented by specific chaperones.

    • Colin Kleanthous

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