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Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.
Identification of the monocarboxylate transporter 1 as a target of a new class of immunosuppressants shows that aerobic glycolysis and lactate release are essential for the proliferation of activated lymphocytes.
During the past century, the sea lamprey colonized the Great Lakes of North America and decimated the commercial fishing industry. The isolation and characterization of a migratory pheromone from the sea lamprey expands options for control of this invading species.
In the brain, neurotransmitter-receptor binding represents the moment of stereochemical recognition in which one neuron senses the signal sent by another. Submillisecond time-resolved FTIR spectroscopy now provides a first glimpse of the generative protein-ligand interactions that lead to glutamate receptor ion channel activation.
Cross-species quorum sensing in bacteria is mediated by a small molecule autoinducer, AI-2. It has now been demonstrated that AI-2–mediated signaling can be sabotaged by bacteria that degrade AI-2.
Kinesins are the molecular motors responsible for movement of vesicles inside cells. Evidence is now presented for how kinesin moves forward, as well as side to side.
Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.