Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 21 Issue 7, July 2019


Suppression of rhoGAPs by G-actin

See Diring et al.

Image: Jessica Diring (The Francis Crick Institute) and Jeroen Claus (Phospho Biomedical Animation). Cover Design: Lauren Heslop.

News & Views

  • Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin-5 complexes, thus shedding light on specific cargo packaging mechanisms.

    • Gonçalo Rodrigues
    • Haiying Zhang
    • David Lyden
    News & Views


  • Different subclones cooperate to support tumour heterogeneity and growth, but the effect on metastasis is unclear. A new study now shows that, as non-cell-autonomous drivers, minor cancer cell subclones instigate growth at distant sites of otherwise non-metastatic cancer cells. This is mediated systemically by perturbation in the metastatic tissue.

    • Luigi Ombrato
    • Ilaria Malanchi
    News & Views
  • The ability of cancer cells to adapt to external and internal stresses is critical for tumourigenesis. A new study now shows that the integrated stress response is critical for tumour cell adaptation to stress induced by c-MYC activation, providing mechanistic insights into tumour responses to intrinsic stresses with implications for cancer therapies.

    • Kirk A. Staschke
    • Ronald C. Wek
    News & Views
Top of page ⤴

Review Articles

  • In this Review, the authors survey key advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials.

    • Michele De Luca
    • Alessandro Aiuti
    • Pamela Gehron Robey
    Review Article
Top of page ⤴


Top of page ⤴

Technical Reports

Top of page ⤴

Amendments & Corrections

Top of page ⤴


Quick links