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Tumour vesicular micromachinery uncovered

Nature Cell Biology volume 21, pages 795–797 (2019)Cite this article

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Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin-5 complexes, thus shedding light on specific cargo packaging mechanisms.

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Fig. 1: EV biogenesis and miRNA packaging.

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Authors and Affiliations

  1. Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

    Gonçalo Rodrigues, Haiying Zhang & David Lyden

  2. Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal

    Gonçalo Rodrigues

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  1. Gonçalo Rodrigues
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  2. Haiying Zhang
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  3. David Lyden
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Correspondence to Haiying Zhang or David Lyden.

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Rodrigues, G., Zhang, H. & Lyden, D. Tumour vesicular micromachinery uncovered. Nat Cell Biol 21, 795–797 (2019). https://doi.org/10.1038/s41556-019-0351-0

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