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Xu, Zhang, Xuan et al. show that PD-1 signalling defines a population of leukaemia stem cells with features of quiescence, drug resistance and protection against cell death, ablation of which suppresses disease progression of mouse and human T-ALL.
Yelagandula et al. show that ZFP462 interacts with G9A/GLP to modulate enhancers with binding sites for embryonic stem cell-specific transcription factors, thereby regulating lineage specification during neural differentiation of mouse embryonic stem cells.
Cui et al. identify an important role for MLL3 in regulating the hybrid epithelial–mesenchymal transition state in breast cancer and show that deletion of MLL3 enhances metastatic capacity through increased IFNγ signalling.
Lee et al. uncover a previously uncharacterized role of OASL in virus-induced necroptosis. OASL chaperones the assembly of RIPK3 and ZBP1 via liquid-liquid phase separation, which induces RIPK3 and necroptosis activation, thereby modulating inflammation and host defence against viral infection.