Volume 39 Issue 1, January 2021

Resilient off-the-shelf T cells

Colored scanning electron micrograph of resting human T lymphocytes. Mo et al. present an alloimmune defense receptor that allows allogeneic T cells to resist rejection by the host immune system by deleting activated host T and NK cells.

See Mo et al.

Image: Steve Gschmeissner/Science Photo Library/Getty. Cover Design: Erin Dewalt.

Editorial

Messengers of hope

Emergency Use Authorizations for two mRNA COVID-19 vaccines represent a turning point in the pandemic. They also herald a new era for vaccinology.

Editorial 29 Dec 2020

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News

BTK blockers make headway in multiple sclerosis

By targeting both arms of the immune system, not just B cells, brain-penetrant inhibitors of Bruton’s tyrosine kinase could improve on anti-CD20 therapy for patients with multiple sclerosis.

Elie Dolgin
News 11 Jan 2021
First small-molecule drug targeting RNA gains momentum

The new drug not only is a boon for patients with spinal muscular atrophy, but also may spearhead the development of further chemical RNA modulators for a broad range of conditions.

Cormac Sheridan
News 11 Jan 2021
FDA clears first drug for premature aging disease

News in Brief 11 Jan 2021
Hunt for improved monoclonals against coronavirus gathers pace

Following mixed results in the clinic against COVID-19, antibody engineers are further optimizing SARS-CoV-2 antibodies with the aim of improving outcomes.

Ken Garber
News 11 Jan 2021
Thumbs up for cholesterol-slashing siRNA blockbuster

News in Brief 11 Jan 2021
Antibody–drug conjugates for cancer score with ROR1

News in Brief 11 Jan 2021
AstraZeneca joins Russia to boost coronavirus vaccine

News in Brief 11 Jan 2021
Around the world in a month

News in Brief 11 Jan 2021

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Correspondence

The Organoid Cell Atlas

Christoph Bock
Michael Boutros
Robert G. J. Vries
Correspondence Open Access 31 Dec 2020

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Obituary

Ananda Mohan ‘Al’ Chakrabarty 1938–2020

Neil Davey
Randall Ray Rader
Debabrata Chakravarti
Obituary 16 Dec 2020

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Features

Patents
- An administrative fix for manufacturing process patent thickets
  
  Biosimilar manufacturing process patent applications first filed more than a year after the biologic is approved, which represent the largest source of patent assertions in biosimilar litigation, could be addressed without requiring intervention by either the courts or Congress.
  
  Arti K. Rai
  W. Nicholson Price II
  Patents 11 Jan 2021
- Circular RNA
  
  Recent patents regarding the preparation, amplification and therapeutic use of circular RNA.
  
  Patents 11 Jan 2021

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News & Views

Safety questions for AAV gene therapy

A long-term study of AAV therapy in dogs finds clonal expansions and vector integrations.

Charles P. Venditti
News & Views 16 Nov 2020
Podcast
- Forum: The T cell wars
  
  Podcast 08 Dec 2020

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Research

Matters Arising
- EEG-based model and antidepressant response
  
  Gustav Nilsonne
  Frank E. Harrell Jr
  Matters Arising 14 Dec 2020
- Reply to: EEG-based model and antidepressant response
  
  Wei Wu
  Diego A. Pizzagall
  Amit Etkin
  Matters Arising 14 Dec 2020
Brief Communications
- Cell type prioritization in single-cell data
  
  The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.
  
  Michael A. Skinnider
  Jordan W. Squair
  Grégoire Courtine
  Brief Communication 20 Jul 2020
Letters
- Glycosylase base editors enable C-to-A and C-to-G base changes
  
  New base editors change C to A in bacteria and C to G in mammalian cells.
  
  Dongdong Zhao
  Ju Li
  Xueli Zhang
  Letter 20 Jul 2020
- CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
  
  A new base editor enables the creation of C-to-G base changes in human cells.
  
  Ibrahim C. Kurt
  Ronghao Zhou
  J. Keith Joung
  Letter 20 Jul 2020
Articles
- A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells
  
  AAV therapy in dogs leads to clonal expansions of transduced cells.
  
  Giang N. Nguyen
  John K. Everett
  Denise E. Sabatino
  Article 16 Nov 2020
- Engineered off-the-shelf therapeutic T cells resist host immune rejection
  
  Off-the-shelf CAR T cells avoid immune rejection in mouse models of allogeneic cancer cell therapy.
  
  Feiyan Mo
  Norihiro Watanabe
  Maksim Mamonkin
  Article 13 Jul 2020
- Inducible de novo expression of neoantigens in tumor cells and mice
  
  A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.
  
  Martina Damo
  Brittany Fitzgerald
  Nikhil S. Joshi
  Article 27 Jul 2020
- Imaging volumetric dynamics at high speed in mouse and zebrafish brain with confocal light field microscopy
  
  A new imaging method enables deep imaging of neural networks.
  
  Zhenkun Zhang
  Lu Bai
  Kai Wang
  Article 10 Aug 2020
- Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
  
  The enzymatic properties of RNA-guided nucleases are revealed through massively parallel analysis.
  
  Stephen K. Jones Jr
  John A. Hawkins
  Ilya J. Finkelstein
  Article 07 Sept 2020
- Optimization of AsCas12a for combinatorial genetic screens in human cells
  
  Improved Cas12a variants and sgRNA design rules enhance genome-wide screens.
  
  Peter C. DeWeirdt
  Kendall R. Sanson
  John G. Doench
  Article 13 Jul 2020
Resources
- A unified catalog of 204,938 reference genomes from the human gut microbiome
  
  More than 200,000 gut prokaryotic reference genomes and the proteins they encode are collated, providing comprehensive resources for microbiome researchers.
  
  Alexandre Almeida
  Stephen Nayfach
  Robert D. Finn
  Resource Open Access 20 Jul 2020

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Amendments & Corrections

Author Correction: Supporting US public health experts

Ron Cohen
Cedric Francois
Sandy Zweifach
Author Correction 17 Dec 2020
Author Correction: Why the European Union needs a national GMO opt-in mechanism

Dennis Eriksson
Eugénia de Andrade
Tomáš Vaněk
Author Correction 18 Dec 2020
Publisher Correction: Glycosylase base editors enable C-to-A and C-to-G base changes

Dongdong Zhao
Ju Li
Xueli Zhang
Publisher Correction 29 Jul 2020

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Careers & Recruitment

Career Feature
- Immersive virtual reality as a competitive training strategy for the biopharma industry
  
  Immersive virtual reality simulations tailored to aspiring industry operators in biopharma manufacturing could become a cost-effective alternative to real-life training for teaching practical skills.
  
  Philip Wismer
  Ainara Lopez Cordoba
  Morten Otto Alexander Sommer
  Career Feature 11 Jan 2021
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 11 Jan 2021

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Volume 39 Issue 1, January 2021

Resilient off-the-shelf T cells

Editorial

News

Correspondence

Obituary

Features

Patents

News & Views

Podcast

Research

Matters Arising

Brief Communications

Letters

Articles

Resources

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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