Volume 37 Issue 10, October 2019

Supercool extensions to human liver storage

The scarcity of organs for transplantation could be addressed in part by extending viable preservation time of retrieved organs. Using an ice-free supercooling approach, Uygun and colleagues extend preservation of human livers by 27 hours. The image shows the liver during machine perfusion, when it is preconditioned with protective agents for supercooled storage.

See de Vries et al.

Image: Jeffrey Andree, Korkut Uygun and Reinier de Vries. Cover Design: Erin Dewalt.

Editorial

Opening the door to backroom biologics

What would a world look like in which biohackers had access to automated drug-production platforms?

Editorial 02 Oct 2019

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News

Anti-CD3 drug keeps diabetes at bay

No drug has ever delayed islet cell destruction. Now that teplizumab has, the challenge turns to identifying eligible recipients for the treatment.

Elie Dolgin
News 02 Sept 2019
Lung Biotechnology tags iBio for bioink production

News in Brief 02 Oct 2019
DTC pharmacogenomics testing under scrutiny

News in Brief 02 Oct 2019
First gene therapy for β-thalassemia approved

Bluebird Bio’s gene therapy eliminates the need for blood transfusions in patients with β-thalassemia.

Charlotte Harrison
News 08 Sept 2019
Biotech giant helps itself without swallowing Galapagos whole

A ten-year collaboration gives biotech giant Gilead first rights to all of Galapagos’s pipeline.

Melanie Senior
News 21 Aug 2019
New antibodies best ZMapp in Ebola trial

News in Brief 02 Oct 2019
Around the world in a month

News in Brief 02 Oct 2019
First Rounders Podcast
- First Rounders: Pardis Sabeti
  
  First Rounders Podcast 02 Oct 2019
Data Page
- Collaborative networks in gene editing
  
  Ying Huang
  Alan Porter
  Rodolphe Barrangou
  Data Page 02 Oct 2019

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Correspondence

A shot in the arm for new antibiotics

Kevin Outterson
Correspondence 02 Oct 2019
Database shares that transform research subjects into partners

Robert Kain
Scott Kahn
Dawn Barry
Correspondence 19 Sept 2019
Data privacy in the age of personal genomics

Dennis Grishin
Kamal Obbad
George M. Church
Correspondence 19 Sept 2019

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Features

Patents
- How does emerging patent case law in the US and Europe affect precision medicine?
  
  How will today’s patent law affect tomorrow’s innovation in the areas of biomarkers and nature-based products; diagnostics; and algorithms, big data and AI?
  
  Mateo Aboy
  Kathleen Liddell
  Timo Minssen
  Patents 02 Oct 2019
- Proteomics
  
  Recent patents related to methods of proteomic screening, identification and analysis.
  
  Patents 02 Oct 2019

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News & Views

Human organs come out of the deep cold

Livers are stored in a supercooled state for extended periods, an approach that could expand access to liver transplantation.

Barry J. Fuller
Alexander Petrenko
Edgardo Guibert
News & Views 09 Sept 2019
Modeling human lung infections in mice

Respiratory pathogens and the human immune response they elicit can now be studied in humanized mice.

Hergen Spits
Julien Villaudy
News & Views 10 Sept 2019

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Research

Letters
- Supercooling extends preservation time of human livers
  
  Preservation of human livers at subzero temperatures with ice-free supercooling extends ex vivo organ life.
  
  Reinier J. de Vries
  Shannon N. Tessier
  Korkut Uygun
  Letter 09 Sept 2019
- De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
  
  Mitochondrial DNA mutations in iPSCs can render them immunogenic.
  
  Tobias Deuse
  Xiaomeng Hu
  Sonja Schrepfer
  Letter 19 Aug 2019
- Adenine base editors catalyze cytosine conversions in human cells
  
  In addition to causing A-to-G base transitions, adenine base editors also cause C base substitutions
  
  Heon Seok Kim
  You Kyeong Jeong
  Sangsu Bae
  Letter 23 Sept 2019
- Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics
  
  Dereplication by inactivation of antibiotic production clusters in actinomycetes enables antibiotic discovery.
  
  Elizabeth J. Culp
  Grace Yim
  Gerard D. Wright
  Letter 09 Sept 2019
Articles
- Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome
  
  High-fidelity reads improve variant detection and genome assembly on the PacBio platform.
  
  Aaron M. Wenger
  Paul Peluso
  Michael W. Hunkapiller
  Article 12 Aug 2019
- Precision mouse models with expanded tropism for human pathogens
  
  Implantation of lung tissue into humanized mice enables in vivo study of the human immune response to pathogens.
  
  Angela Wahl
  Chandrav De
  J. Victor Garcia
  Article 26 Aug 2019
- Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
  
  Combinatorial development of heterocyclic lipidoids yields efficient mRNA vaccine vehicles that activate immune cells via the STING pathway.
  
  Lei Miao
  Linxian Li
  Daniel G. Anderson
  Article 30 Sept 2019
- Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice
  
  The authors designed stapled antimicrobial peptides that have potent antibacterial activity in mice and limited toxicity.
  
  Rida Mourtada
  Henry D. Herce
  Loren D. Walensky
  Article 19 Aug 2019
- Self-organizing neuruloids model developmental aspects of Huntington’s disease in the ectodermal compartment
  
  Micropatterning generates the four ectodermal cell types of human neurulation.
  
  Tomomi Haremaki
  Jakob J. Metzger
  Ali H. Brivanlou
  
  Collection:
  
  Stem cells from development to the clinic
  Article 09 Sept 2019
- Multi-input chemical control of protein dimerization for programming graded cellular responses
  
  Clinically approved drugs can be used to control chemically induced dimerization and program mammalian cellular behaviors.
  
  Glenna Wink Foight
  Zhizhi Wang
  Dustin J. Maly
  Article 09 Sept 2019
- Blood metabolome predicts gut microbiome α-diversity in humans
  
  Multiomics reveals that almost half of gut microbiome diversity in humans can be explained by 40 blood metabolites.
  
  Tomasz Wilmanski
  Noa Rappaport
  Nathan D. Price
  Article 02 Sept 2019
- Data storage in DNA with fewer synthesis cycles using composite DNA letters
  
  Toward more storage for less synthesis using a six-letter composite DNA alphabet.
  
  Leon Anavy
  Inbal Vaknin
  Zohar Yakhini
  Article 09 Sept 2019

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Amendments & Corrections

Author Correction: Characterization of cell fate probabilities in single-cell data with Palantir

Manu Setty
Vaidotas Kiseliovas
Dana Pe’er
Author Correction 18 Sept 2019
Author Correction: Data storage in DNA with fewer synthesis cycles using composite DNA letters

Leon Anavy
Inbal Vaknin
Zohar Yakhini
Author Correction 16 Sept 2019
Publisher Correction: Your DNA broker

Laura DeFrancesco
Ariel Klevecz
Publisher Correction 09 Sept 2019
Publisher Correction: Emerging technologies for improved deep brain stimulation

Hayriye Cagnan
Timothy Denison
Peter Brown
Publisher Correction 09 Sept 2019

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Careers & Recruitment

Career Feature
- First-hand, immersive full-body experiences with living cells through interactive museum exhibits
  
  A museum exhibit that enables direct full-body interactions with living microbes immerses human visitors into the microscopic world and could inform the design of future educational life-science technologies.
  
  Amy T. Lam
  Joyce Ma
  Ingmar H. Riedel-Kruse
  Career Feature 02 Oct 2019
People
- People
  
  A sample of goings on in and around the biotech and pharmaceutical industry.
  
  People 02 Oct 2019

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Volume 37 Issue 10, October 2019

Supercool extensions to human liver storage

Editorial

News

First Rounders Podcast

Data Page

Correspondence

Features

Patents

News & Views

Research

Letters

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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