Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DISEASE MODELS

Modeling human lung infections in mice

Nature Biotechnology volume 37, pages 1129–1130 (2019)Cite this article

Subjects

Respiratory pathogens and the human immune response they elicit can now be studied in humanized mice.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Humanized mice to study human-tropic pathogens.

References

  1. Wahl, A. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0225-9 (2019).

    Article  PubMed  Google Scholar 

  2. Shultz, L. D., Brehm, M. A., Garcia-Martinez, J. V. & Greiner, D. L. Nat. Rev. Immunol. 12, 786–798 (2012).

    Article  CAS  Google Scholar 

  3. Rongvaux, A. et al. Annu. Rev. Immunol. 31, 635–674 (2013).

    Article  CAS  Google Scholar 

  4. Gimeno, R. et al. Blood 104, 3886–3893 (2004).

    Article  CAS  Google Scholar 

  5. Traggiai, E. et al. Science 304, 104–107 (2004).

    Article  CAS  Google Scholar 

  6. Ito, M. et al. Blood 100, 3175–3182 (2002).

    Article  CAS  Google Scholar 

  7. Shultz, L. D. et al. J. Immunol. 174, 6477–6489 (2005).

    Article  CAS  Google Scholar 

  8. Melkus, M. W. et al. Nat. Med. 12, 1316–1322 (2006).

    Article  CAS  Google Scholar 

  9. Ito, R., Takahashi, T., Katano, I. & Ito, M. Cell. Mol. Immunol. 9, 208–214 (2012).

    Article  CAS  Google Scholar 

  10. Strick-Marchand, H. et al. PLoS One 10, e0119820 (2015).

    Article  Google Scholar 

  11. Dusséaux, M. et al. Gastroenterology 153, 1647–1661.e9 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Amsterdam Infection & Immunity Institute, Department of Experimental Immunology, Amsterdam UMC, Amsterdam, the Netherlands

    Hergen Spits

  2. AIMM Therapeutics BV, Amsterdam, the Netherlands

    Julien Villaudy

Authors
  1. Hergen Spits
    View author publications

    Search author on:PubMed Google Scholar

  2. Julien Villaudy
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Hergen Spits.

Ethics declarations

Competing interests

J.V. is an employee of and stockholder in AIMM Therapeutics. H.S. owns stock in AIMM Therapeutics and consults for GlaxoSmithKline.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Spits, H., Villaudy, J. Modeling human lung infections in mice. Nat Biotechnol 37, 1129–1130 (2019). https://doi.org/10.1038/s41587-019-0269-x

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41587-019-0269-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology