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A light micrograph showing the layered structure of the retina. da Cruz et al. transplant a patch of retinal pigment epithelium derived from human embryonic stem cells into the eyes of two individuals with age-related macular degeneration (p 328). Credit: Alvin Telser/Science Photo Library
Ultra-long read, single-molecule nanopore sequencers are beginning to find an expanding set of research applications in both human genomics and pathogenomics.
Our annual survey highlights how immune-oncology and screens based on the application of cutting-edge omics technologies are providing a launchpad for a succession of startups interrogating biology across biomedicine.
An examination of the prosecution and maintenance histories of approximately 2.7 million US patent applications indicates that women have less favorable outcomes than men.
Metabolomics activity screening can identify small-molecule metabolites that are readily available and can be used to alter phenotypes, including stem cell differentiation, T-cell survival, oligodendrocyte maturation, and insulin signaling.
A series of feedforward-stabilized bacterial gene promoters produce near-identical expression levels regardless of copy number changes due to altered genetic context, strain or growth conditions.
Engaging undergraduates in computational tasks can improve genomic research laboratory productivity, benefiting both students and senior laboratory members.