Volume 32 Issue 7, July 2014

Volume 32 Issue 7

Oranges, pummelos, clementines and mandarins. Wu et al. generate a highquality reference haploid genome of a clementine and resequence eight related species to reveal the ancestry of citrus varieties (p 656). Credit: Toni Siebert

Editorial

  • Editorial |

    Bioscience job creation is now less about the 'knowledge-based' economy than the 'service-based' economy.

  • Editorial |

    The Battelle/BIO report on the US bioeconomy is too inclusive in some places and too exclusive in others.

News

Correction

News

News Feature

  • News Feature |

    Despite the complexity of drought tolerance, researchers are making progress in the search for crops that can produce seed with limited water. Emily Waltz reports.

    • Emily Waltz

Bioentrepreneur

  • Bioentrepreneur |

    A life science business plan competition designed to catalyze young bioentrepreneurs shows the way for other regions seeking to galvanize biotech startups.

    • John Daley
    •  & Alicia Shiu

Correspondence

Commentary

  • Commentary |

    Myriad took no prisoners on its way to the top of the molecular diagnostics field. That strategy is unlikely to endure.

    • Jacob S Sherkow
    •  & Christopher Scott

Feature

  • Feature |

    2013 was truly a year to remember for the public biotech sector, with the largest wave of IPOs since the 2000–2001 bubble.

    • Stacy Lawrence
    •  & Riku Lahteenmaki

Patents

News & Views

  • News & Views |

    Simultaneous measurement of paired TCR sequences and gene expression in single T cells improves the characterization of T cells.

    • Ning Jiang
    • , Shuqi Zhang
    •  & Keyue Ma
  • News & Views |

    Clarification of the genetic relationships among species opens new possibilities for enhancing citrus diversity and disease resistance.

    • Riccardo Velasco
    •  & Concetta Licciardello
  • News & Views |

    New fabric-like sensors measure and transmit mechanical strain on the skin with unprecedented sensitivity.

    • Michael J Cima

Analysis

  • Analysis |

    For several cancer types analyzed by The Cancer Genome Atlas project, predictions of patient survival were not substantially improved by using common data mining approaches to combine traditional clinical variables with molecular profiling data.

    • Yuan Yuan
    • , Eliezer M Van Allen
    • , Larsson Omberg
    • , Nikhil Wagle
    • , Ali Amin-Mansour
    • , Artem Sokolov
    • , Lauren A Byers
    • , Yanxun Xu
    • , Kenneth R Hess
    • , Lixia Diao
    • , Leng Han
    • , Xuelin Huang
    • , Michael S Lawrence
    • , John N Weinstein
    • , Josh M Stuart
    • , Gordon B Mills
    • , Levi A Garraway
    • , Adam A Margolin
    • , Gad Getz
    •  & Han Liang

Brief Communication

Article

  • Article | | Open Access

    Genome sequences of nine species of citrus, including oranges, pummelos and mandarins, reveal pathways of domestication and provide resources for breeding.

    • G Albert Wu
    • , Simon Prochnik
    • , Jerry Jenkins
    • , Jerome Salse
    • , Uffe Hellsten
    • , Florent Murat
    • , Xavier Perrier
    • , Manuel Ruiz
    • , Simone Scalabrin
    • , Javier Terol
    • , Marco Aurélio Takita
    • , Karine Labadie
    • , Julie Poulain
    • , Arnaud Couloux
    • , Kamel Jabbari
    • , Federica Cattonaro
    • , Cristian Del Fabbro
    • , Sara Pinosio
    • , Andrea Zuccolo
    • , Jarrod Chapman
    • , Jane Grimwood
    • , Francisco R Tadeo
    • , Leandro H Estornell
    • , Juan V Muñoz-Sanz
    • , Victoria Ibanez
    • , Amparo Herrero-Ortega
    • , Pablo Aleza
    • , Julián Pérez-Pérez
    • , Daniel Ramón
    • , Dominique Brunel
    • , François Luro
    • , Chunxian Chen
    • , William G Farmerie
    • , Brian Desany
    • , Chinnappa Kodira
    • , Mohammed Mohiuddin
    • , Tim Harkins
    • , Karin Fredrikson
    • , Paul Burns
    • , Alexandre Lomsadze
    • , Mark Borodovsky
    • , Giuseppe Reforgiato
    • , Juliana Freitas-Astúa
    • , Francis Quetier
    • , Luis Navarro
    • , Mikeal Roose
    • , Patrick Wincker
    • , Jeremy Schmutz
    • , Michele Morgante
    • , Marcos Antonio Machado
    • , Manuel Talon
    • , Olivier Jaillon
    • , Patrick Ollitrault
    • , Frederick Gmitter
    •  & Daniel Rokhsar
  • Article |

    A new algorithm for analyzing genome sequences of family members helps identify genes associated with disease.

    • Hao Hu
    • , Jared C Roach
    • , Hilary Coon
    • , Stephen L Guthery
    • , Karl V Voelkerding
    • , Rebecca L Margraf
    • , Jacob D Durtschi
    • , Sean V Tavtigian
    • , Shankaracharya
    • , Wilfred Wu
    • , Paul Scheet
    • , Shuoguo Wang
    • , Jinchuan Xing
    • , Gustavo Glusman
    • , Robert Hubley
    • , Hong Li
    • , Vidu Garg
    • , Barry Moore
    • , Leroy Hood
    • , David J Galas
    • , Deepak Srivastava
    • , Martin G Reese
    • , Lynn B Jorde
    • , Mark Yandell
    •  & Chad D Huff
  • Article |

    Genome-wide analysis of Cas9-DNA interactions in mammalian cells shows widespread binding but low levels of cleavage.

    • Xuebing Wu
    • , David A Scott
    • , Andrea J Kriz
    • , Anthony C Chiu
    • , Patrick D Hsu
    • , Daniel B Dadon
    • , Albert W Cheng
    • , Alexandro E Trevino
    • , Silvana Konermann
    • , Sidi Chen
    • , Rudolf Jaenisch
    • , Feng Zhang
    •  & Phillip A Sharp

Careers and Recruitment

  • Careers and Recruitment |

    Gamified laboratory simulations motivate students and improve learning outcomes compared with traditional teaching methods.

    • Mads T Bonde
    • , Guido Makransky
    • , Jakob Wandall
    • , Mette V Larsen
    • , Mikkel Morsing
    • , Hanne Jarmer
    •  & Morten O A Sommer
  • Careers and Recruitment |