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Illustration of diverse RNA hairpins (yellow and orange) binding to coat proteins (blue) inside an assembling MS2A viral capsid. Buenrostro et al. repurpose an Illumina sequencer (yielding raw black and white fluorescence images in background) for high-throughput measurement of RNA-protein binding affinities to study structure-function relationships (represented by the hexagonal RNA hairpin diagrams) (p 562). Credit: Carlos L. Araya
Industry needs to fully embrace efforts by regulators to release clinical trial data on approved products, despite lingering concerns over the public release of confidential business information. It is simply the right thing to do.
The creation of the Global Health Security Agenda is a key step in the goal of combatting outbreaks in an increasingly interconnected world. It is too bad that the initiative is so woefully underfunded.
Current clinical trial approaches in rare disease test one drug on one indication defined by a clinical phenotype. For targeted drugs, grouping patients by molecular etiology would make much more sense.
Confidential business information is commonly used to hide data about industry products from public view. Researchers, regulators and companies are currently struggling to redefine who needs to know what about commercial products and when they need to know it.
The rate of invention may be a valuable metric for identifying strategic R&D investments to enhance knowledge creation, translational value and economic potential from NIH-supported research.
Hematopoietic differentiation of human pluripotent stem cells is directed to either the definitive or primitive program, a step toward the generation of hematopoietic stem cells.
Repurposing a DNA sequencing instrument for high-throughput analysis of RNA-protein interactions enables detailed analysis of sequence-function relationships.