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Volume 31 Issue 7, July 2013

Confocal image of liver section from mice injected with lipid nanoparticles carrying siRNA (red). Gilleron et al. (p 638) and Sahay et al. (p 653) dissect molecular mechanisms of siRNA delivery to guide the development of RNAi therapeutics. Credit: Jerome Gilleron, Anja Zeigerer and Marino Zerial.

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  • The Myriad decision to overturn human gene patents is the least of concerns for a diagnostic sector struggling to attract investment.

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  • A truly original thinker and pioneering entrepreneur.

    • James W Larrick
    • Volker Schellenberger
    • Carlos F Barbas III
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  • New research will shed light on claims from commercial banks that cord blood–derived stem cells can be used in diseases beyond hematological disorders. Sarah Webb investigates.

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  • Next-generation sequencing has provided long-sought-after noninvasive tests for prenatal screening, and a small cadre of companies has stepped up to push it into the clinic at warp speed.

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Analysis

  • Optimized algorithms from the field of electrical-signal processing improve the identification of genomic signals from diverse high-throughput sequencing experiments, such as ChIP-seq, DNase-seq and FAIRE-seq.

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    • Masafumi Muratani
    • Shyam Prabhakar
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