Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Organic synthesis by in vitro evolution

A method for DNA-templated ligation allows in vitro evolution of organic polymers.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The principle of DNA-encoded and DNA-directed oligomer ligation1.

References

  1. Niu, J., Hili, R. & Liu, D.R. Nat. Chem. 5, 282–292 (2013).

    Article  CAS  Google Scholar 

  2. Brenner, S. & Lerner, R.A. Proc. Natl. Acad. Sci. USA 89, 5381–5383 (1992).

    Article  CAS  Google Scholar 

  3. Mannocci, L., Leimbacher, M., Wichert, M., Scheuermann, J. & Neri, D. Chem. Commun. (Camb.) 47, 12747–12753 (2011).

    Article  CAS  Google Scholar 

  4. Nielsen, P.E., Egholm, M., Berg, R.H. & Buchardt, O. Science 254, 1497–1500 (1991).

    Article  CAS  Google Scholar 

  5. Chouikhi, D. et al. Chemistry 18, 12698–12704 (2012).

    Article  CAS  Google Scholar 

  6. Hansen, M.H. et al. J. Am. Chem. Soc. 131, 1322–1327 (2009).

    Article  CAS  Google Scholar 

  7. Tuerk, C. & Gold, L. Science 249, 505–510 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter E Nielsen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nielsen, P. Organic synthesis by in vitro evolution. Nat Biotechnol 31, 613–614 (2013). https://doi.org/10.1038/nbt.2632

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2632

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research