News & Views in 2006

Glycomics offers exciting possibilities for discovering serum biomarkers.

The genome sequence of a bacterium that degrades marine hydrocarbons should facilitate bioremediation efforts.

The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface.

Small interfering RNA is targeted to a specific cell type in vivo using an RNA aptamer.

Adeno-associated virus mediates correction of genetic mutations in mouse liver.

The use of primordial germ cells to transmit genetic modifications through the chicken germ line is a significant advance for avian biology.

Inhibitors of the PI3 kinase family of enzymes show promise for treating brain tumors.

A new animal study shows that too much RNAi is lethal.

A consensus epitope prediction approach identifies the epitopes responsible for 95% of the murine T-cell response to vaccinia virus.

A new community resource for fission yeast offers genome-wide data on open reading frames (ORFs) and protein localization.

Proteins that could not be displayed on the surface of phage are now amenable to this powerful selection technology.

A method for amplifying DNA from single bacterial cells shows promise for complete genome sequencing.

A new approach to reducing the immunological side effects of gene therapy exploits microRNA to knock down transgene expression in immune cells.

Spermatogonial stem cells in adult testis may be more versatile than embryonic stem cells.

Unraveling how a soil-dwelling bacterium kills insects promises to deliver new biopesticides.

A method for altering the substrate specificity of LuxR proteins may facilitate the engineering of artificial communication systems among cells.